Structural Genomics of Microbes: an Objective

Overview

Journal Curr Opin Struct Biol

Date 2000 Jun 14

PMID 10851198

Citations 10

Authors

S H Kim

Affiliations

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Abstract

A comparison of the genome sequences of more than 20 microorganisms reveals that a large fraction of the genes have unknown functions. Determining the structures of the proteins coded by these genes may provide additional key information in an effort to uncover the molecular functions of such proteins and new protein fold patterns. Using existing technology, it is possible to obtain a complete sequence complement and a near complete structural complement for a small microbial genome. Such information may provide a comprehensive view of a small organism, which, in turn, can serve as a platform for understanding more complex organisms.

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