Depression of the T-lymphocyte Response to Phytohaemagglutinin by Renal Cells

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1976 Jun 1

PMID 1084822

Citations 2

Authors

T E Miller

L Scott

G Simpson

D J Ormrod

Affiliations

Soon will be listed here.

Abstract

The lymphocytic infiltrate in the renal parenchyma is a consistent histological feature of pyelonephritis, but the role of the lymphocytes in the immunobiology of pyelonephritis is not known. In this investigation the influence of the local environment on the potential function of T lymphocytes in the kidney was investigated. The experiments have demonstrated that the response of rat lymphocytes to stimulation in vitro with phytohaemagglutinin (PHA) can be entirely ablated by normal kidney cells. Even when the number of kidney cells added to cultures of lymphocytes was less than 2% of the cells present some ablation of T-lymphocyte function could be detected. The biological characteristics of the factor causing ablation of the PHA responsiveness of T lymphocytes were partially characterized and the factor appears to have unique features that differentiate it from lymphocyte chalones and other tissue factors influencing lymphocyte function. The results may explain recent findings where T lymphocytes were found to be the predominant lymphocyte in the inflammatory infiltrate but were not responsive to PHA in vitro.

Citing Articles

Cellular basis of host defence in pyelonephritis. I. Chronic infection.

Miller T, Findon G, Cawley S Br J Exp Pathol. 1986; 67(1):13-23.

PMID: 3511938 PMC: 2013060.

Modification by suppressor cells and serum factors of the cell-mediated immune response in experimental pyelonephritis.

Miller T, Scott L, Stewart E, North D J Clin Invest. 1978; 61(4):964-72.

PMID: 350900 PMC: 372614. DOI: 10.1172/JCI109021.

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