Inhibitory Effect of Sheep Erythrocyte Fragments on Rosette Formation of Human T Lymphocytes with Sheep Red Blood Cells

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1976 May 1

PMID 1084245

Citations 1

Authors

N Taniguchi

N Okuda

N Moriya

T Miyawaki

T Nagaoki

Affiliations

Soon will be listed here.

Abstract

The effect of sheep red blood cells (SRBC) fragments on rosette formation of human peripheral T lymphocytes with SRBC was evaluated on the active and total T-rosette tests. The rosetting capacity of active rosette-forming cells was selectively and nearly completely inhibited by the pretreatment of lymphocytes with SRBC fragments. The decrease in total rosettes by blocking with SRBC fragments was almost parallel to that of active rosettes. SRBC fragments had no inhibitory effect on the rosetting capacity of a lymphocyte population in which active rosette-forming cells were removed by gradient centrifugation. These results suggested that active rosette-forming cells in human T lymphocytes have the receptors of high affinity for SRBC and these receptors readily bind SRBC fragments, resulting in block of rosette formation.

Citing Articles

Characterization of pig lymphocyte receptors for allogeneic and non-allogeneic erythrocytes. I. Apparent common identity of both receptors.

Salmon H Clin Exp Immunol. 1982; 48(3):574-80.

PMID: 6180852 PMC: 1536598.

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