Role of Membrane Structures in B-lymphocyte Activation. The Effect of Binding Anti-immunoglobulin, Aggregated IgG and Immune Complexes

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1976 Apr 1

PMID 1083830

Citations 3

Authors

R Ramasamy

Affiliations

Soon will be listed here.

Abstract

It is shown that the binding of bivalent anti-immunoglobulin preparations to the surface immunoglobulin of murine B lymphocytes as well as the binding of aggregates of IgG or immune complexes does not lead to detectable increase in cell division in microcultures. Treating lymphocytes with immune complexes and aggregated IgG does not abolish the subsequent mitogenic response induced by LPS. The background mitosis observed in culture is inhibited with anti-immunoglobulin antibodies.

Citing Articles

Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments.

MORGAN E, Walker S, Thoman M, Weigle W J Exp Med. 1980; 152(1):113-23.

PMID: 7400754 PMC: 2185893. DOI: 10.1084/jem.152.1.113.

Human B cell activation. Evidence for diverse signals provided by various monoclonal anti-IgM antibodies.

Rudich S, Winchester R, Mongini P J Exp Med. 1985; 162(4):1236-55.

PMID: 2413155 PMC: 2187873. DOI: 10.1084/jem.162.4.1236.

B-lymphocytes activation by the Fc region of IgG.

Berman M, Weigle W J Exp Med. 1977; 146(1):241-56.

PMID: 68990 PMC: 2180743. DOI: 10.1084/jem.146.1.241.

References

Marchalonis J, Cone R . Biochemical and biological characteristics of lymphocyte surface immunoglobulin. Transplant Rev. 1973; 14:3-49. DOI: 10.1111/j.1600-065x.1973.tb00101.x. View

Dickler H, Sachs D . Evidence for identity or close association of the Fc receptor of B lymphocytes and alloantigens determined by the Ir region of the H-2 complex. J Exp Med. 1974; 140(3):779-96. PMC: 2139622. DOI: 10.1084/jem.140.3.779. View

Sell S . Development of restrictions in the expression of immunoglobulin specificities by lymphoid cells. Transplant Rev. 1970; 5:19-44. DOI: 10.1111/j.1600-065x.1970.tb00355.x. View

Moller G . Induction of DNA synthesis in normal human lymphocyte cultures by antigen-antibody complexes. Clin Exp Immunol. 1969; 4(1):65-82. PMC: 1579050. View

Andersson J, Bullock W, Melchers F . Inhibition of mitogenic stimulation of mouse lymphocytes by anti-mouse immunoglobulin antibodies. I. Mode of action. Eur J Immunol. 1974; 4(11):715-22. DOI: 10.1002/eji.1830041103. View

Elson C, Singh J, Taylor R . The effect of capping by anti-immunoglobulin antibody on the expression of cell surface immunoglobulin and on lymphocyte activation. Scand J Immunol. 1973; 2(2):143-9. DOI: 10.1111/j.1365-3083.1973.tb02025.x. View

WEBER W . Avian B lymphocyte subpopulations: origins and functional capacities. Transplant Rev. 1975; 24:113-58. DOI: 10.1111/j.1600-065x.1975.tb00167.x. View

Munro A, Taussig M . Two genes in the major histocompatibility complex control immune response. Nature. 1975; 256(5513):103-6. DOI: 10.1038/256103a0. View

Coutinho A . The theory of the 'one nonspecific signal' model for b cell activation. Transplant Rev. 1975; 23:49-65. DOI: 10.1111/j.1600-065x.1975.tb00148.x. View

10.

Basten A, Miller J, Abraham R . Relationship between Fc receptors, antigen-binding sites on T and B cells, and H-2 complex-associated determinants. J Exp Med. 1975; 141(3):547-60. PMC: 2189703. DOI: 10.1084/jem.141.3.547. View

11.

Ramasamy R, Munro A, Milstein C . Possible role for the Fc receptor on B lymphocytes. Nature. 1974; 249(457):573-4. DOI: 10.1038/249573a0. View

12.

Vitetta E, UHR J . Synthesis, transport, dynamics and fate of cell surface Ig and alloantigens in murine lymphocytes. Transplant Rev. 1973; 14:50-75. DOI: 10.1111/j.1600-065x.1973.tb00102.x. View

13.

Sell S, Rowe D, Gell P . Studies on rabbit lymphocytes in vitro. 3. Proteins, RNA, and DNA synthesis by lymphocyte cultures after stimulation with phytohaemagglutinin, with staphylococcal filtrate, with antiallotype serum, and with heterologous antiserum to rabbit whole.... J Exp Med. 1965; 122(4):823-39. PMC: 2138086. DOI: 10.1084/jem.122.4.823. View

14.

Moller G, Coutinho A . Role of C'3 and Fc receptors in B-lymphocyte activation. J Exp Med. 1975; 141(3):647-63. PMC: 2189709. DOI: 10.1084/jem.141.3.647. View

15.

Janossy G, Greaves M . Functional analysis of murine and human B lymphocyte subsets. Transplant Rev. 1975; 24:177-236. DOI: 10.1111/j.1600-065x.1975.tb00169.x. View

16.

Kishimoto T, Ishizaka K . Regulation of antibody response in vitro. IX. Induction of secondary anti-hapten IgG antibody response by anti-immunoglobulin and enhancing soluble factor. J Immunol. 1975; 114(2 Pt 1):585-91. View