Antemortem Diagnosis of Leigh's Disease: Role of Magnetic Resonance Studies

Overview

Journal Indian J Pediatr

Specialty Pediatrics

Date 1996 Sep 1

PMID 10830040

Citations 3

Authors

D Ghosh

S Pradhan

Affiliations

Soon will be listed here.

Abstract

A two-and-a-half-year-old male child presented with recurrent attacks of intractable vomiting, psychomotor retardation since 14 months of age. He had also lower cranial nerve palsy and corticospinal involvement. Magnetic resonance imaging had shown multiple well circumscribed areas of hypointusity in T1 weighted image which were brightly hyperintense in heavily T2-weighted image. The lesions were seen in basal ganglia, thalamii and brainstem and spared mamillary bodies. Magnetic resonance spectroscopy demonstrated lactate peak in the affected areas confirming the diagnosis of Leigh's disease. The child responded well to large dose of vitamin 'B' therapy.

Citing Articles

A rare mitochondrial disorder: Leigh syndrome--a case report.

Shrikhande D, Kalakoti P, Syed M, Ahya K, Singh G Ital J Pediatr. 2010; 36:62.

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Profile of inborn errors of metabolism in a tertiary care centre PICU.

Kamate M, Chetal V, Kulgod V, Patil V, Christopher R Indian J Pediatr. 2010; 77(1):57-60.

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PMID: 15572826 DOI: 10.1007/BF02828121.

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