[Autolymphocytotoxins (CoCoCy) in Different Forms of Hepatitis and Cirrhosis (author's Transl)]

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1976 Mar 1

PMID 1082962

Citations 2

Authors

J Bertrams

E Kuwert

H SELMAIR

H E Reis

W Wiese

Affiliations

Soon will be listed here.

Abstract

Sera of altogether 282 patients with different forms of hepatitis and cirrhosis were screened for cold reacting complement dependant auto-lympho-cytotoxins (CoCoCy). These antibodies are 19S-IgM-immunoglobins and have no HLA-antigen-specificity. CoCoCy occurred in 48% of the patients with chronic aggressive hepatitis (CAH), in 14% of the patients with chronic persistent hepatitis (CPH) and in intermediate rates in the sera of patients with acute hepatitis. No correlations was found between CoCoCy and hepatitis B-antigen (HB-Ag). CoCoCy could be demonstrated also in 20% of the sera of a HB-Ag-positive and in 6% of a HB-Ag-negative control group. The serum concentration of CoCoCy is low. CoCoCy seems to be of T-cell-specificity and to reflect the overall-immunoreactivity without relation to the specificity of the antigenic stimulus. Thus demonstration of CoCoCy may be of pathogeneic and pathodynamic rather than of diagnostic interest.

Citing Articles

Autoantibodies and serum inhibition factors (sif) in patients with myocarditis.

Maisch B, Berg P, Kochsiek K Klin Wochenschr. 1980; 58(5):219-25.

PMID: 6995705 DOI: 10.1007/BF01476967.

[Cold-lymphocytotoxic antibodies in the sera of cervix-carcinoma patients].

Muller N, Koenig U Blut. 1977; 34(6):479-83.

PMID: 301763 DOI: 10.1007/BF00996875.

References

Michlmayr G, ASAMER H, Huber C, HUBER H . [Antibodies against autologous lymphocytes in lupus erythematosus]. Klin Wochenschr. 1972; 50(9):484-6. DOI: 10.1007/BF01487608. View

Naito S, Mickey M, Hirata A, Terasaki P . Autolymphocytotoxins following immunization by pregnancy, transplantation, and disease. Tissue Antigens. 1971; 1(5):219-28. DOI: 10.1111/j.1399-0039.1971.tb00099.x. View

Thomas D, Phillips B . Evidence for membrane antigen(s) specific for human B lymphoblasts. Clin Exp Immunol. 1973; 14(1):91-6. PMC: 1553853. View

KAPLAN M, Grady G . Serum-hepatitis antigen in chronic hepatitis and primary biliary cirrhosis. Lancet. 1971; 1(7691):159-61. DOI: 10.1016/s0140-6736(71)91933-7. View

DUDLEY F, Fox R, Sherlock S . Relationship of hepatitis-associated antigen (H.A.A.) to acute and chronic liver injury. Lancet. 1971; 2(7714):1-3. DOI: 10.1016/s0140-6736(71)90001-8. View

Kapp J, Hoher P, Kuwert E, Thraenhart O, Paar D, Hengstebeck W . [A sensitive Australia-antigen complement fixation test (CFT) and its comparison with the Ouchterlony- and counter current electrophoresis techniques]. Med Microbiol Immunol. 1971; 157(1):58-74. DOI: 10.1007/BF02121292. View

Thomas D . Antibodies specific for human T lymphocytes in cold agglutinin and lymphocytotoxic sera. Eur J Immunol. 1973; 3(12):824-8. DOI: 10.1002/eji.1830031216. View

Bertrams J, Kuwert E, NOLL K . [Leukocyte isoantibodies. 3. Identification and characterization of monospecific HL-A antiserums for histocompatibility testing]. Z Med Mikrobiol Immunol. 1971; 156(2):132-48. View

Mayer S, Falkenrodt A, Tongio M . HL-A antibodies and cold lymphocytotoxins. Tissue Antigens. 1974; 4(4):387-94. DOI: 10.1111/j.1399-0039.1974.tb00266.x. View

10.

VIDO I, SELMAIR H, WILDHIRT E, Ortmans H . [Prognosis of chronic hepatitis. 1. Forms and developmental stages]. Dtsch Med Wochenschr. 1969; 94(43):2215-6 passim. DOI: 10.1055/s-0028-1110419. View

11.

SELMAIR H, VIDO I, Kaboth U, Schober A . [Australia(SH)-antigen findings in florid and cured chronic-persistent hepatites]. Dtsch Med Wochenschr. 1971; 96(49):1908-11. DOI: 10.1055/s-0028-1110242. View

12.

BOZICEVICH J, NASOU J, KAYHOE D . Desoxyribonucleic acid (DNA)-bentonite flocculation test for lupus erythematosus. Proc Soc Exp Biol Med. 1960; 103:636-40. DOI: 10.3181/00379727-103-25620. View

13.

Terasaki P, Mottironi V, Barnett E . Cytotoxins in disease. Autocytotoxins in lupus. N Engl J Med. 1970; 283(14):724-8. DOI: 10.1056/NEJM197010012831403. View

14.

Mayer S, Falkenrodt A, Tongio M . Cold lymphocytotoxins in infections and parasitic infestations. Tissue Antigens. 1973; 3(6):431-8. DOI: 10.1111/j.1399-0039.1973.tb00513.x. View

15.

Thomas D . Antibodies to membrane antigen(s) common to thymocytes and a subpopulation of lymphocytes in infectious-mononucleosis sera. Lancet. 1972; 1(7747):399-403. DOI: 10.1016/s0140-6736(72)90854-9. View

16.

Kreisler M, Hirata A, Terasaki P . Cytotoxins in disease. 3. Antibodies against lymphocytes produced by vaccination. Transplantation. 1970; 10(5):411-5. View

17.

Pesendorfer F, Krassnitzky O, Wewalka F . [Immunoelectrophoretic detection of the "hepatitis associated antigen" (Au-SH-antigen)]. Klin Wochenschr. 1970; 48(1):58-9. DOI: 10.1007/BF01486135. View

18.

Kaboth U, Schober A, ARNDT H, VIDO I, SELMAIR H, Gallasch E . [Australia (SH) antigen findings in patients with liver diseases and blood donors]. Dtsch Med Wochenschr. 1970; 95(43):2157-65. DOI: 10.1055/s-0028-1108798. View

19.

Knapp W, PATEISKY K . Lymphocytotoxins in myasthenia gravis. Z Immunitatsforsch Exp Klin Immunol. 1972; 144(4):329-34. View

20.

Kuwert E, Bertrams J . Leukocyte iso- and autoantibodies in multiple sclerosis (MS) with special regard to complement-dependent cold-reacting auto-lymphocytotoxins (CoCoCy). Eur Neurol. 1972; 7(1):65-73. DOI: 10.1159/000114413. View