A New Primate Model for Multiple Sclerosis in the Common Marmoset

Overview

Journal Immunol Today

Specialty Allergy & Immunology

Date 2000 May 29

PMID 10825741

Citations 25

Authors

B A t Hart

M van Meurs

H P Brok

L Massacesi

J Bauer

L Boon

R E Bontrop

J D Laman

Affiliations

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Abstract

Experimental autoimmune encephalomyelitis (EAE) in outbred marmoset monkeys (Callithrix jacchus) is a recently developed nonhuman primate model of multiple sclerosis. Here, Bert 't Hart and colleagues compare this model to EAE in rhesus monkeys, highlighting autoimmune mechanisms in CNS inflammation and demyelination, including the role of major histocompatibility complex restriction and preclinical evaluation of innovative immunotherapies.

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