[Investigations on the Aminoglycoside Inactivating Enzyme AAC-(6') IV (author's Transl)]

Overview

Journal Infection

Date 1979 Jan 1

PMID 108221

Citations 1

Authors

B Wiedemann

G TETZLAFF

Affiliations

Soon will be listed here.

Abstract

In Serratia marcescens and Pseudomonas aeruginosa from clinical specimen acetyltransferase AAC-(6') IV leads to varying phaenotypically expressed resistance to aminoglycoside antibiotics. The substrate profile and the rate of inactivation of the enzymes investigated are almost identical with each other and with the enzyme of P. aeruginosa GN 315. The enzymes cannot be associated with R factors by the standard methods for conjugation, transformation, density gradient centrifugation and agarose gel electrophoresis.

Citing Articles

Evidence for a chromosomal site specifying amikacin resistance in multiresistant Serratia marcescens.

John Jr J, McNeill W, PRICE K, Kresel P Antimicrob Agents Chemother. 1982; 21(4):587-91.

PMID: 7044303 PMC: 181946. DOI: 10.1128/AAC.21.4.587.

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