Genetic Determination of the Immune Response in Mice to Cells of Different Histological Type

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1979 Apr 1

PMID 108209

Citations 1

Authors

V A Lavrovsky

V K Viksler

Y A Yurchenko

V A Razvorotnev

Affiliations

Soon will be listed here.

Abstract

The intensity of the cellular immune response to strong transplantation antigens of the H-2 complex is related to the histological type of cells taken for immunization. Splenic cells from C3H mice immunized BALB/c mice better than cells of non-lymphoid origin from the same donor. The reverse was observed when, instead of BALB/c mice, C57B1/6 and A/He were used in immunization experiments. Analysis of the inheritance of this immunization pattern studied in mice of the first generation from various crosses between strains (BALB/c, C57B1/6 and A/He) and in mice from backcrosses has demonstrated that this immunization pattern is not inherited as a simple Mendelian character. Therefore, it could be supposed that efficiency of immunological control of cells having different histological types, may be genetically determined.

Citing Articles

Enhanced immune reactivity to hepatoma 22a cells in MTV-infected compared with MTV-free C3H mice.

Lavrovsky V, Viksler V Immunology. 1981; 44(4):671-6.

PMID: 6274791 PMC: 1555000.

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