Developmental Studies of Brca1 and Brca2 Knock-out Mice

Overview

Journal J Mammary Gland Biol Neoplasia

Date 2000 May 20

PMID 10819537

Citations 33

Authors

R Hakem

J L de la Pompa

T W Mak

Affiliations

Soon will be listed here.

Abstract

In humans, the inheritance of mutations in the breast cancer susceptibility genes BRCA1 and BRCA2 increases the risk of developing breast and ovarian cancer. To study their biological function and to create animal models for these cancer susceptibility genes, several strains of mice mutated in the homologous genes Brca1 and Brca2 have been generated by gene targeting. Analyses of these "knock-out" mouse mutants have provided invaluable knowledge about the function of these genes. Brca1 and Brca2 null mutants are similar in phenotype: mutations in both genes result in embryonic lethality and the developing embryos show signs of a cellular proliferation defect associated with activation of the p53 pathway. The significance of this activation, as well as the role of these cancer susceptibility genes in DNA damage repair, is discussed.

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