Serum Lymphocytotoxins in Inflammatory Bowel Disease. Studies of Frequency and Specificity for Lymphocyte Subpopulations

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1975 Sep 11

PMID 1081934

Citations 10

Authors

R G STRICKLAND

E M Friedler

C A Henderson

I D Wilson

R D Williams Jr

Affiliations

Soon will be listed here.

Abstract

Serum cold-reactive lymphocytotoxin (LCT) was detected in twenty-two of fifty-six (40%) patients with inflammatory bowel disease (IBD). The frequency of LCT detection was similar in Crohn's disease and ulcerative colitis. Cytotoxicity testing against T or B cell-enriched peripheral blood lymphocytes from normal donors, together with absorption experiments, indicated that LCT in IBD was reactive against determinants on both cell subpopulations. Reactivity against T cells from patients with common variable immunodeficiency was significantly less than with normal donor T cells. LCT in IBD could not be related to prior allogeneic sensitization and its presence appeared to be unrelated to disease activity or drug therapy. No correlation was found between LCT and peripheral blood T- or B-cell numbers. The present findings suggest the need for further investigation of the role of infectious agents in the pathogenesis of IBD.

Citing Articles

Lymphocytotoxins in leprosy and in asymptomatic hepatitis B virus infection.

Serjeantson S, Dry P Clin Exp Immunol. 1980; 39(2):289-96.

PMID: 7389201 PMC: 1538069.

Cold-reactive lymphocytotoxins in Crohn's disease and ulcerative colitis. I. Incidence and characterization.

Brown D, Jewell D Clin Exp Immunol. 1982; 49(1):67-74.

PMID: 6982133 PMC: 1536647.

Idiopathic Inflammation Bowel Disease: is there a role for immunological mechanisms in etiopathogenesis?.

SHORTER R Gastroenterol Jpn. 1982; 17(5):476-88.

PMID: 6757043 DOI: 10.1007/BF02774726.

Seropositivity in Dutch Crohn's disease patients against primed nude mouse lymph nodes, and the difference with lymphocytotoxic antibodies.

Pena A, Kuiper I, Walvoort H, Verspaget H, Weterman I, Ruitenberg E Gut. 1986; 27(12):1426-33.

PMID: 3542740 PMC: 1433979. DOI: 10.1136/gut.27.12.1426.

CD5+ B cells are decreased in peripheral blood of patients with Crohn's disease.

Neil G, Summers R, Cheyne B, Capenter C, Huang W, Kansas G Dig Dis Sci. 1992; 37(9):1390-5.

PMID: 1380423 DOI: 10.1007/BF01296009.

References

Waldmann T, Durm M, Broder S, Blackman M, Blaese R, Strober W . Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia. Lancet. 1974; 2(7881):609-13. DOI: 10.1016/s0140-6736(74)91940-0. View

Williams Jr R, Emmons J, Yunis E . Studies of human sera with cytotoxic activity. J Clin Invest. 1971; 50(7):1514-24. PMC: 292092. DOI: 10.1172/JCI106637. View

Kreisler M, Hirata A, Terasaki P . Cytotoxins in disease. 3. Antibodies against lymphocytes produced by vaccination. Transplantation. 1970; 10(5):411-5. View

Winchester R, Winfield J, Siegal F, Wernet P, Bentwich Z, KUNKEL H . Analyses of lymphocytes from patients with rheumatoid arthritis and systemic lupus erythematosus. Occurrence of interfering cold-reactive antilymphocyte antibodies. J Clin Invest. 1974; 54(5):1082-92. PMC: 301656. DOI: 10.1172/JCI107852. View

Thomas D . Antibodies to membrane antigen(s) common to thymocytes and a subpopulation of lymphocytes in infectious-mononucleosis sera. Lancet. 1972; 1(7747):399-403. DOI: 10.1016/s0140-6736(72)90854-9. View

Kreisler M, Naito S, Terasaki P . Cytotoxins in disease. V. Various diseases. Transplant Proc. 1971; 3(1):112-4. View

Jondal M, Holm G, Wigzell H . Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972; 136(2):207-15. PMC: 2139198. DOI: 10.1084/jem.136.2.207. View

Wybran J, Carr M, Fudenberg H . The human rosette-forming cell as a marker of a population of thymus-derived cells. J Clin Invest. 1972; 51(10):2537-43. PMC: 332950. DOI: 10.1172/JCI107069. View

Cave D, MITCHELL D, Kane S, Brooke B . Further animal evidence of a transmissible agent in Crohn's disease. Lancet. 1973; 2(7838):1120-2. DOI: 10.1016/s0140-6736(73)90936-7. View

10.

Ooi B, Orlina A, MASAITIS L . Lymphocytotoxins in primary renal disease. Lancet. 1974; 2(7893):1348-50. DOI: 10.1016/s0140-6736(74)92215-6. View

11.

Weeke B, BENDIXEN G . Serum immunoglobulins and organ-specific, cellular hypersensitivity in ulcerative colitis and Crohn's disease. Acta Med Scand. 1969; 186(1-2):87-91. DOI: 10.1111/j.0954-6820.1969.tb01444.x. View

12.

MITCHELL D, Rees R . Agent transmissible from Crohn's disease tissue. Lancet. 1970; 2(7665):168-71. DOI: 10.1016/s0140-6736(70)92532-8. View

13.

Knapp W, PATEISKY K . Lymphocytotoxins in myasthenia gravis. Z Immunitatsforsch Exp Klin Immunol. 1972; 144(4):329-34. View

14.

Goldberg L, Cunningham J, Terasaki P . Lymphocytotoxins and pernicious anemia. Blood. 1972; 39(6):862-5. View

15.

Korsmeyer S, STRICKLAND R, Wilson I, Williams Jr R . Serum lymphocytotoxic and lymphocytophilic antibody activity in inflammatory bowel disease. Gastroenterology. 1974; 67(4):578-83. View

16.

Wigzell H, Sundqvist K, YOSHIDA T . Separation of cells according to surface antigens by the use of antibody-coated columns. Fractionation of cells carrying immunoglobulins and blood group antigen. Scand J Immunol. 1972; 1(1):75-87. DOI: 10.1111/j.1365-3083.1972.tb03737.x. View

17.

Lies R, Messner R, Williams Jr R . Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus. Arthritis Rheum. 1973; 16(3):369-75. DOI: 10.1002/art.1780160312. View

18.

Wernet P, KUNKEL H . Antibodies to a specific surface antigen of T cells in human sera inhibiting mixed leukocyte culture reactions. J Exp Med. 1973; 138(4):1021-6. PMC: 2180576. DOI: 10.1084/jem.138.4.1021. View

19.

Ooi B, Orlina A, MASAITIS L, First M, POLLAK V . Lymphocytotoxins in aging. Transplantation. 1974; 18(2):190-2. View

20.

Greaves M, Brown G . Purification of human T and B lymphocytes. J Immunol. 1974; 112(1):420-3. View