IL-10 is Necessary for the Expression of Airway Hyperresponsiveness but Not Pulmonary Inflammation After Allergic Sensitization

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2000 May 17

PMID 10811896

Citations 51

Authors

M J Makela

A Kanehiro

L Borish

A Dakhama

J Loader

A Joetham

Z Xing

M Jordana

G L Larsen

E W Gelfand

Affiliations

Soon will be listed here.

Abstract

Cytokines play an important role in modulating inflammatory responses and, as a result, airway tone. IL-10 is a regulatory cytokine that has been suggested for treatment of asthma because of its immunosuppressive and anti-inflammatory properties. In contrast to these suggestions, we demonstrate in a model of allergic sensitization that mice deficient in IL-10 (IL-10-/-) develop a pulmonary inflammatory response but fail to exhibit airway hyperresponsiveness in both in vitro and in vivo assessments of lung function. Reconstitution of these deficient mice with the IL-10 gene fully restores development of airway hyperresponsiveness comparable to control mice. These results identify an important role of IL-10, downstream of the inflammatory cascade, in regulating the tone of the airways after allergic sensitization and challenge.

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