Mammalian Follicular Development and Atresia: Role of Apoptosis

Overview

Journal Biol Signals Recept

Date 2000 May 16

PMID 10810203

Citations 30

Authors

E Asselin

C W Xiao

Y F Wang

B K Tsang

Affiliations

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Abstract

The regulation of follicular development and atresia is a complex process and involves interactions between endocrine factors (gonadotropins) and intraovarian regulators (sex steroids, growth factors and cytokines) in the control of follicular cell fate (i.e. proliferation, differentiation and programmed cell death). Granulosa and theca cells are key players in this fascinating process. As atresia is the fate of most follicles, understanding of how these physiological regulators participate in determining the destiny of the follicle (to degenerate or to ovulate) at cellular and subcellular levels is fundamental. This short review summarizes the role of intraovarian modulators of programmed cell death in the induction of atresia during follicular development.

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