Effects of Reproduction on Spontaneous Development of Endometrial Adenocarcinomas and Mammary Tumors in Donryu Rats

Overview

Journal Jpn J Cancer Res

Specialty Oncology

Date 2000 May 11

PMID 10804284

Citations 3

Authors

T Nagaoka

K Takegawa

M Takeuchi

A Maekawa

Affiliations

Soon will be listed here.

Abstract

Effects of reproduction on spontaneous development of uterine endometrial adenocarcinomas and mammary tumors in Donryu rats were investigated. While the incidence of endometrial adenocarcinomas in Donryu rats was not influenced by a single reproductive experience (SRE), it showed a tendency to decrease in animals having three reproductive experiences (TRE), compared to the nulliparous case (NRE). In addition, both SRE and TRE animals showed delayed occurrence and decreased incidences and mean numbers of mammary tumors, along with reduced incidences of proliferative lesions in the pituitary gland and mucinous epithelium in the vagina. The appearance-time and incidences of persistent estrus in TRE rats were delayed and low, respectively, compared to the SRE and NRE values. The hormonal environment was altered in both groups, the prolactin level in TRE especially being decreased. These results suggest that suppression of the occurrence of endometrial adenocarcinomas and mammary tumors in rats experiencing reproduction is associated with change in the hormonal milieu.

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References

Nagaoka T, Onodera H, Matsushima Y, Todate A, Shibutani M, Ogasawara H . Spontaneous uterine adenocarcinomas in aged rats and their relation to endocrine imbalance. J Cancer Res Clin Oncol. 1990; 116(6):623-8. DOI: 10.1007/BF01637084. View

Kelsey J, Gammon M, John E . Reproductive factors and breast cancer. Epidemiol Rev. 1993; 15(1):36-47. DOI: 10.1093/oxfordjournals.epirev.a036115. View

Russo J, Tay L, Russo I . Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res Treat. 1982; 2(1):5-73. DOI: 10.1007/BF01805718. View

Kitamura T, Nishimura S, Sasahara K, Yoshida M, Ando J, Takahashi M . Transplacental administration of diethylstilbestrol (DES) causes lesions in female reproductive organs of Donryu rats, including endometrial neoplasia. Cancer Lett. 1999; 141(1-2):219-28. DOI: 10.1016/s0304-3835(99)00108-1. View

Fernandez-Ruiz J, Cebeira M, Agrasal C, Tresguerres J, Esquifino A, Ramos J . Effect of elevated prolactin levels on the synthesis and release of catecholamines from the adrenal medulla in female rats. Neuroendocrinology. 1987; 45(3):208-11. DOI: 10.1159/000124727. View

Musey V, Collins D, Musey P, PREEDY J . Long-term effect of a first pregnancy on the secretion of prolactin. N Engl J Med. 1987; 316(5):229-34. DOI: 10.1056/NEJM198701293160501. View

Kvale G, Heuch I, Ursin G . Reproductive factors and risk of cancer of the uterine corpus: a prospective study. Cancer Res. 1988; 48(21):6217-21. View

Parazzini F, La Vecchia C, Negri E, Fedele L, BALOTTA F . Reproductive factors and risk of endometrial cancer. Am J Obstet Gynecol. 1991; 164(2):522-7. DOI: 10.1016/s0002-9378(11)80012-8. View

WELSCH C, Nagasawa H . Prolactin and murine mammary tumorigenesis: a review. Cancer Res. 1977; 37(4):951-63. View

10.

Brinton L, Berman M, Mortel R, Twiggs L, Barrett R, Wilbanks G . Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case-control study. Am J Obstet Gynecol. 1992; 167(5):1317-25. DOI: 10.1016/s0002-9378(11)91709-8. View

11.

Negri E, La Vecchia C, Duffy S, Bruzzi P, Parazzini F, Day N . Age at first and second births and breast cancer risk in biparous women. Int J Cancer. 1990; 45(3):428-30. DOI: 10.1002/ijc.2910450308. View

12.

Fox H . Endometrial carcinogenesis and its relation to oestrogens. Pathol Res Pract. 1984; 179(1):13-9. DOI: 10.1016/S0344-0338(84)80055-2. View

13.

Young S . Induction of mammary carcinoma in hypophysectomized rats treated with 3-methylcholanthrene, oestradiol-17 beta, progesterone and growth hormone. Nature. 1961; 190:356-7. DOI: 10.1038/190356a0. View

14.

Henderson B, Casagrande J, Pike M, Mack T, Rosario I, Duke A . The epidemiology of endometrial cancer in young women. Br J Cancer. 1983; 47(6):749-56. PMC: 2011352. DOI: 10.1038/bjc.1983.127. View

15.

ZIEL H . Estrogen's role in endometrial cancer. Obstet Gynecol. 1982; 60(4):509-15. View

16.

Yu M, Gerkins V, Henderson B, Brown J, Pike M . Elevated levels of prolactin in nulliparous women. Br J Cancer. 1981; 43(6):826-31. PMC: 2010727. DOI: 10.1038/bjc.1981.121. View

17.

LINGEMAN C . Hormones and hormonomimetic compounds in the etiology of cancer. Recent Results Cancer Res. 1979; 66:1-48. DOI: 10.1007/978-3-642-81267-5_1. View

18.

Bernstein L, Pike M, Ross R, Judd H, Brown J, Henderson B . Estrogen and sex hormone-binding globulin levels in nulliparous and parous women. J Natl Cancer Inst. 1985; 74(4):741-5. View

19.

Ewertz M, Duffy S, Adami H, Kvale G, Lund E, Meirik O . Age at first birth, parity and risk of breast cancer: a meta-analysis of 8 studies from the Nordic countries. Int J Cancer. 1990; 46(4):597-603. DOI: 10.1002/ijc.2910460408. View

20.

Watanabe K, Sasano H, Harada N, Ozaki M, Niikura H, Sato S . Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies. Am J Pathol. 1995; 146(2):491-500. PMC: 1869837. View