Circulating Carcinoembryonic Antigen Immune Complexes in Sera of Patients with Carcinomata of the Gastrointestinal Tract

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1979 Feb 1

PMID 108040

Citations 11

Authors

F A Anderer

Affiliations

Soon will be listed here.

Abstract

The sera of patients with histologically proven carcinomata of the gastrointestinal tract were fractionated by gel filtration and the fractions assayed for the presence of free carcinoembryonic antigen (CEA) binding immunoglobulins and CEA immune complexes by radioimmuno-double-diffusion, using 125I-CEA as a marker. In eleven out of thirteen cases with disease recurrence, the presence of CEA-IgM complexes was observed, and in three out of thirteen cases the presence of CEA-IgG complexes, could be demonstrated. Free CEA-binding immunoglobulins could not be detected.

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Are circulating CEA immune complexes a prognostic marker in patients with carcinoma of the gastrointestinal tract?.

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[Relapse prognosis for patients with adenocarcinoma of the gastrointestinal tract on the basis of carcinoembryonic antigen (CEA) and its circulating immune complexes (author's transl)].

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