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Correlation Between Three-dimensional Structure and Chemical Reactivity of Transfer RNA

Overview
Journal Nucleic Acids Res
Publisher Oxford University Press
Specialty Biochemistry
Date 1974 Jul 1
PMID 10793725
Citations 18
Authors
J D Robertus
J E Ladner
J T Finch
D Rhodes
R S Brown
B F Clark
A Klug
Affiliations
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Abstract

The bases of yeast tRNA(Phe) which react with carbodiimide and methoxyamine have been determined and this information has been combined with chemical modification studies of other workers to produce a composite picture of base accessibility in this tRNA. The results are compared with the three-dimensional structure which we have recently determined. The bases which react chemically lie in exposed positions in the three-dimensional model and those which do not are either in the double helical stem regions or else are involved in maintaining the tertiary structure through pairing or stacking interactions.

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References
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