Wiskott-Aldrich Syndrome Protein is Necessary for Efficient IgG-mediated Phagocytosis

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2000 Apr 26

PMID 10779443

Citations 61

Authors

R Lorenzi

P M Brickell

D R Katz

C Kinnon

A J Thrasher

Affiliations

Soon will be listed here.

Abstract

Interactions between the Wiskott-Aldrich (WAS) protein (WASp), small GTPases, and the cytoskeletal organizing complex Arp2/3 appear to be critical for the transduction of signals from the cell membrane to the actin cytoskeleton in hematopoietic cells. This study shows that Fcgamma-receptor (FcgammaR)-mediated phagocytosis is impaired in WASp-deficient peripheral blood monocytes, and that in macrophages, formation of the actin cup and local recruitment of tyrosine phosphorylated proteins is markedly attenuated. Results also show that, in normal macrophages, WASp itself is actively recruited to the cup, suggesting that assembly of this specialized cytoskeletal structure is dependent on its expression. (Blood. 2000;95:2943-2946)

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