Characterization of Two Divergent Lineages of Macaque Rhadinoviruses Related to Kaposi's Sarcoma-associated Herpesvirus

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2000 Apr 25

PMID 10775636

Citations 39

Authors

E R Schultz

G W Rankin Jr

M P Blanc

B W Raden

C C Tsai

T M Rose

Affiliations

Soon will be listed here.

Abstract

We have cloned and characterized the entire DNA polymerase gene and flanking regions from Kaposi's sarcoma-associated herpesvirus (KSHV) and two closely related macaque homologs of KSHV, retroperitoneal fibromatosis-associated herpesvirus-Macaca nemestrina (RFHVMn) and -Macaca mulatta (RFHVMm). We have also identified and partially characterized the corresponding genomic region of another KSHV-like herpesvirus, provisionally named "M. nemestrina rhadinovirus type 2 (MneRV-2)," with close similarity to rhesus rhadinovirus (RRV). A sequence comparison of these four macaque viruses and two KSHV-like gammaherpesviruses recently identified in African green monkeys, Chlorocebus rhadinovirus types 1 and 2 (ChRV-1 and ChRV-2) reveals the presence of two distinct lineages of KSHV-like rhadinoviruses in Old World primates. The first rhadinovirus lineage consists of KSHV and its closely related homologs RFHVMn, RFHVMm, and ChRV-1, while the second more distantly related lineage consists of RRV, MneRV-2, and ChRV-2. Our findings raise the possibility of the existence of another human KSHV-like herpesvirus belonging to the second rhadinovirus lineage.

Citing Articles

Protein Degradation by Gammaherpesvirus RTAs: More Than Just Viral Transactivators.

Combs L, Combs J, McKenna R, Toth Z Viruses. 2023; 15(3).

PMID: 36992439 PMC: 10055789. DOI: 10.3390/v15030730.

Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases.

Moraes S, Becker J, Moghadasi S, Shaban N, Auerbach A, Cheng A Elife. 2022; 11.

PMID: 36458685 PMC: 9747160. DOI: 10.7554/eLife.83893.

Kaposi's Sarcoma-Associated Herpesvirus, the Etiological Agent of All Epidemiological Forms of Kaposi's Sarcoma.

Jary A, Veyri M, Gothland A, Leducq V, Calvez V, Marcelin A Cancers (Basel). 2021; 13(24).

PMID: 34944828 PMC: 8699694. DOI: 10.3390/cancers13246208.

Dhingra A, Ganzenmueller T, Hage E, Suarez N, Matz-Rensing K, Widmer D Emerg Infect Dis. 2019; 25(8):1548-1551.

PMID: 31310220 PMC: 6649351. DOI: 10.3201/eid2508.181802.

Experimental co-transmission of Simian Immunodeficiency Virus (SIV) and the macaque homologs of the Kaposi Sarcoma-Associated Herpesvirus (KSHV) and Epstein-Barr Virus (EBV).

Bruce A, Barcy S, Staheli J, Bielefeldt-Ohmann H, Ikoma M, Howard K PLoS One. 2018; 13(11):e0205632.

PMID: 30444879 PMC: 6239284. DOI: 10.1371/journal.pone.0205632.

References

Shibata R, Maldarelli F, Siemon C, Matano T, Parta M, Miller G . Infection and pathogenicity of chimeric simian-human immunodeficiency viruses in macaques: determinants of high virus loads and CD4 cell killing. J Infect Dis. 1997; 176(2):362-73. DOI: 10.1086/514053. View

Desrosiers R, Sasseville V, Czajak S, Zhang X, Mansfield K, Kaur A . A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus. J Virol. 1997; 71(12):9764-9. PMC: 230286. DOI: 10.1128/JVI.71.12.9764-9769.1997. View

Rose T, Strand K, Schultz E, Schaefer G, Rankin Jr G, Thouless M . Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species. J Virol. 1997; 71(5):4138-44. PMC: 191572. DOI: 10.1128/JVI.71.5.4138-4144.1997. View

Russo J, Bohenzky R, Chien M, Chen J, Yan M, Maddalena D . Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A. 1996; 93(25):14862-7. PMC: 26227. DOI: 10.1073/pnas.93.25.14862. View

Page R . TreeView: an application to display phylogenetic trees on personal computers. Comput Appl Biosci. 1996; 12(4):357-8. DOI: 10.1093/bioinformatics/12.4.357. View

Chang Y, Moore P . Kaposi's Sarcoma (KS)-associated herpesvirus and its role in KS. Infect Agents Dis. 1996; 5(4):215-22. View

Moore P, Gao S, Dominguez G, Cesarman E, Lungu O, Knowles D . Primary characterization of a herpesvirus agent associated with Kaposi's sarcomae. J Virol. 1996; 70(1):549-58. PMC: 189843. DOI: 10.1128/JVI.70.1.549-558.1996. View

Chang Y, Cesarman E, Pessin M, Lee F, Culpepper J, Knowles D . Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994; 266(5192):1865-9. DOI: 10.1126/science.7997879. View

Albrecht J, Nicholas J, Biller D, Cameron K, Biesinger B, Newman C . Primary structure of the herpesvirus saimiri genome. J Virol. 1992; 66(8):5047-58. PMC: 241364. DOI: 10.1128/JVI.66.8.5047-5058.1992. View

10.

Giddens Jr W, Tsai C, Morton W, Ochs H, Knitter G, Blakley G . Retroperitoneal fibromatosis and acquired immunodeficiency syndrome in macaques. Pathologic observations and transmission studies. Am J Pathol. 1985; 119(2):253-63. PMC: 1887907. View

11.

Greensill J, SHELDON J, Renwick N, Beer B, Norley S, Goudsmit J . Two distinct gamma-2 herpesviruses in African green monkeys: a second gamma-2 herpesvirus lineage among old world primates?. J Virol. 2000; 74(3):1572-7. PMC: 111496. DOI: 10.1128/jvi.74.3.1572-1577.2000. View

12.

Albrecht J . Primary structure of the Herpesvirus ateles genome. J Virol. 2000; 74(2):1033-7. PMC: 111628. DOI: 10.1128/jvi.74.2.1033-1037.2000. View

13.

Auerbach M, Czajak S, Johnson W, Desrosiers R, Alexander L . Species specificity of macaque rhadinovirus glycoprotein B sequences. J Virol. 1999; 74(1):584-90. PMC: 111576. DOI: 10.1128/jvi.74.1.584-590.2000. View

14.

Mansfield K, Westmoreland S, DeBakker C, Czajak S, Lackner A, Desrosiers R . Experimental infection of rhesus and pig-tailed macaques with macaque rhadinoviruses. J Virol. 1999; 73(12):10320-8. PMC: 113087. DOI: 10.1128/JVI.73.12.10320-10328.1999. View

15.

Damania B, Li M, Choi J, Alexander L, Jung J, Desrosiers R . Identification of the R1 oncogene and its protein product from the rhadinovirus of rhesus monkeys. J Virol. 1999; 73(6):5123-31. PMC: 112557. DOI: 10.1128/JVI.73.6.5123-5131.1999. View

16.

Searles R, Bergquam E, Axthelm M, Wong S . Sequence and genomic analysis of a Rhesus macaque rhadinovirus with similarity to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. J Virol. 1999; 73(4):3040-53. PMC: 104064. DOI: 10.1128/JVI.73.4.3040-3053.1999. View

17.

Bosch M, Strand K, Rose T . Gammaherpesvirus sequence comparisons. J Virol. 1998; 72(10):8458-9. PMC: 110245. DOI: 10.1128/JVI.72.10.8458-8459.1998. View

18.

Nicholas J, Zong J, Alcendor D, Ciufo D, Poole L, Sarisky R . Novel organizational features, captured cellular genes, and strain variability within the genome of KSHV/HHV8. J Natl Cancer Inst Monogr. 1998; (23):79-88. DOI: 10.1093/oxfordjournals.jncimonographs.a024179. View

19.

Schulz T . Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8). J Gen Virol. 1998; 79 ( Pt 7):1573-91. DOI: 10.1099/0022-1317-79-7-1573. View

20.

Rose T, Schultz E, Henikoff J, Pietrokovski S, McCALLUM C, Henikoff S . Consensus-degenerate hybrid oligonucleotide primers for amplification of distantly related sequences. Nucleic Acids Res. 1998; 26(7):1628-35. PMC: 147464. DOI: 10.1093/nar/26.7.1628. View