A Case of Bilateral Optic Neuropathy in a Patient on Tacrolimus (FK506) Therapy After Liver Transplantation
Overview
Authors
Affiliations
Purpose: To report a case of bilateral optic neuropathy in a patient receiving tacrolimus (FK 506, Prograf; Fujisawa USA, Inc, Deerfield, Illinois) for immunosuppression after orthotropic liver transplantation.
Method: Case report. In a 58-year-old man receiving tacrolimus after orthotropic liver transplantation, serial neuro-ophthalmologic examinations and laboratory studies were performed.
Results: The patient had episodic deterioration of vision in both eyes, with clinical features resembling ischemic optic neuropathies. Deterioration of vision occurred despite discontinuation of the tacrolimus.
Conclusion: Tacrolimus and other immunosuppressive agents may be associated with optic nerve toxicity.
Tacrolimus-Associated Maculopathy in a Patient Following Kidney Transplantation.
Almdallaleh S, Altalhi A, Azzaz K, Oudeh O, Radwan M Cureus. 2024; 16(9):e70157.
PMID: 39463507 PMC: 11506439. DOI: 10.7759/cureus.70157.
Tacrolimus Optic Neuropathy Mimicking Papilledema.
Hussein I, Micieli J Case Rep Ophthalmol. 2022; 13(2):361-367.
PMID: 35811764 PMC: 9209972. DOI: 10.1159/000524699.
Non-pulmonary complications after lung transplantation: Part I.
Kanade R, Kler A, Banga A Indian J Thorac Cardiovasc Surg. 2022; 38(Suppl 2):280-289.
PMID: 35756951 PMC: 9226221. DOI: 10.1007/s12055-021-01223-z.
A Case of Tacrolimus Maculopathy.
Santarelli M, Zeppieri M, Salati C Clin Pract. 2022; 12(3):276-283.
PMID: 35645310 PMC: 9149804. DOI: 10.3390/clinpract12030033.
Tacrolimus induced optic neuropathy in post-lung transplant patients: A series of 3 patients.
Nanda T, Rasool N, Bearelly S Am J Ophthalmol Case Rep. 2021; 22:101056.
PMID: 33778180 PMC: 7985716. DOI: 10.1016/j.ajoc.2021.101056.