The Na+-Ca2+ Exchange Inhibitor KB-R7943 Inhibits High K+-induced Increases in Intracellular Ca2+ Concentration and [3H]noradrenaline Release in the Human Neuroblastoma SH-SY5Y

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2000 Apr 13

PMID 10761983

Citations 2

Authors

H Nakamura

Y Kawasaki

N Arakawa

M Saeki

S Maeda

Y Koyama

A Baba

T Matsuda

Affiliations

Soon will be listed here.

Abstract

The effects of the Na+-Ca2+ exchange inhibitor 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate (KB-R7943) on depolarization-induced Ca2+ signal and [3H]noradrenaline release were examined in SH-SY5Y cells. KB-R7943 at 10 microM significantly inhibited high K+-induced increase in intracellular Ca2+ concentration. KB-R7943 also inhibited high K+-evoked release of [3H]noradrenaline from the cells. These findings suggest that the Na+-Ca2+ exchanger in the reverse mode is involved at least partly in depolarization-induced transmitter release.

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