Prolongation of Islet Allograft Survival Following in Vitro Culture (24 Degrees C) and a Single Injection of ALS

Overview

Journal Science

Specialty Science

Date 1979 Apr 20

PMID 107588

Citations 48

Authors

P E Lacy

J M Davie

E H FINKE

Affiliations

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Abstract

Isolated rat islets remain morphologically and functionally intact during a 7-day period of in vitro culture at 24 degrees C. In vitro culture of islets at 24 degrees C for 7 days prior to transplantation, in conjunction with a single injection of antiserum to lymphocytes into the diabetic recipient, results in islet allograft survival of 100 days when the islets are transplanted across a major histocompatibility barrier.

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