Human Inhibitory and Activating Ig-like Receptors Which Modulate the Function of Myeloid Cells

There is increasing evidence that myeloid cells express several receptor families, which include both inhibitory and stimulatory isoforms. The expression of receptor isoforms with similar specificities but opposite functions on the same cell is intriguing. What might be the interplay between these receptors? Some clues to the answer to this question may come from recent studies on two myeloid receptor families: the ILT/LIR/MIR (immunoglobulin-like transcript/leukocyte Ig-like receptor/monocyte/macrophage Ig-like receptor) and the SIRP (signal-regulatory protein).