Adverse Drug Reactions Among Inpatients in a North Indian Referral Hospital

Overview

Journal Natl Med J India

Specialty General Medicine

Date 2000 Apr 1

PMID 10743370

Citations 13

Authors

R Uppal

R Jhaj

S Malhotra

Affiliations

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Abstract

Background: Monitoring spontaneous adverse drug reactions is one of the epidemiological methods for assessing the safety of drugs in a hospital setting.

Methods: Data on adverse drug reactions (ADRs) were collected over a 3-year period among inpatients in a north Indian referral hospital using the spontaneous ADR monitoring system.

Results: A total of 317 ADRs were reported. Cutaneous reactions (38.8%) and gastrointestinal disturbances (28.4%) made up a large proportion of reported ADRs. Antimicrobial agents, including those used for antituberculosis therapy, were responsible for 47.3% of the events. Radiocontrast dyes, and antineoplastic and psychoactive agents were the other important drugs causing ADRs. No age- or sex-related differences were found in the overall rate of ADRs, though toxic epidermal necrolysis was more frequent in the elderly.

Conclusion: The pattern of ADRs and drugs involved were largely similar to those reported in the western literature.

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