Differential Effects of Melanocortin Peptides on Ingestive Behaviour in Rats: Evidence Against the Involvement of MC(3) Receptor in the Regulation of Food Intake

Overview

Journal Neurosci Lett

Specialty Neurology

Date 2000 Mar 24

PMID 10729619

Citations 13

Authors

A Kask

L Rago

J E Wikberg

H B Schioth

Affiliations

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Abstract

The pro-opiomelanocortin-derived peptides decrease food intake possibly via MC4 receptor. In this study we compared the effects of alpha-melanocyte-stimulating hormone (MSH), beta-MSH and gamma(1)-MSH (0.2, 1.0 and 5.0 microg, i.c.v.) on food intake. alpha-MSH and beta-MSH inhibited spontaneous food intake in a dose dependent manner, whereas the gamma(1)-MSH did not. alpha-MSH and beta-MSH but not gamma(1)-MSH (all 5.0 microg, i.c.v.) inhibited fasting-induced food intake about 50%. None of the three peptides inhibited fluid consumption in water-deprived (24 h) rats. It is suggested that MC(3) receptor, activated selectively by gamma(1)-MSH, is not involved in the regulation of food intake.

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