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Sub-Tenon's Local Anaesthesia: the Effect of Hyaluronidase

Overview
Journal Br J Ophthalmol
Specialty Ophthalmology
Date 2000 Mar 24
PMID 10729306
Citations 6
Authors
S A Rowley
J E Hale
R D Finlay
Affiliations
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Abstract

Aims: A prospective, randomised, double blind study was used to investigate the effect of hyaluronidase on the quality of block achieved with sub-Tenon's local anaesthesia.

Methods: 150 patients scheduled for elective cataract surgery were randomly allocated to either sub-Tenon's block with 3 ml lignocaine 2%/adrenaline 1:200 000 alone or with the addition of 30 IU/ml of hyaluronidase. The blocks were assessed for degree of akinesia and reduction of eyelid movement, and also post-injection and postoperative pain scores.

Results: Akinesia and reduction of eyelid movement measured 10 minutes after injection were significantly better in the group with hyaluronidase added to the anaesthetic solution. Postoperative pain scores were not significantly different between the two groups but the post-injection pain score was greater (marginally significant) in the group with hyaluronidase added.

Conclusion: The addition of hyaluronidase significantly improves the quality of the motor blockade achieved with sub-Tenon's local anaesthesia, but has no effect on the sensory blockade.

Citing Articles

Use of hyaluronidase as an adjunct to local anaesthetic eye blocks to reduce intraoperative pain in adults.

Ruschen H, Aravinth K, Bunce C, Bokre D Cochrane Database Syst Rev. 2018; 3:CD010368.

PMID: 29498413 PMC: 6494176. DOI: 10.1002/14651858.CD010368.pub2.

Safety and Efficacy of Sodium Bicarbonate versus Hyaluronidase in Peribulbar Anaesthesia.

Gupta R, Kapoor G Med J Armed Forces India. 2016; 62(2):116-8.

PMID: 27407875 PMC: 4921994. DOI: 10.1016/S0377-1237(06)80050-X.

Ophthalmic regional blocks: management, challenges, and solutions.

Palte H Local Reg Anesth. 2015; 8:57-70.

PMID: 26316814 PMC: 4550180. DOI: 10.2147/LRA.S64806.

Hyaluronidase in sub-Tenon's anesthesia for phacoemulsification, a double-blind randomized clinical trial.

Sedghipour M, Mahdavifard A, Fouladi R, Gharabaghi D, Rahbani M, Amiraslanzadeh G Int J Ophthalmol. 2012; 5(3):389-92.

PMID: 22773994 PMC: 3388414. DOI: 10.3980/j.issn.2222-3959.2012.03.27.

Allergic reaction to hyaluronidase after retrobulbar anaesthesia: a case series and review.

Delaere L, Zeyen T, Foets B, Van Calster J, Stalmans I Int Ophthalmol. 2008; 29(6):521-8.

PMID: 18784901 DOI: 10.1007/s10792-008-9258-7.

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