In Situ Self Hardening Bioactive Composite for Bone and Dental Surgery

Overview

Journal J Biomater Sci Polym Ed

Specialty Biomedical Engineering

Date 2000 Mar 16

PMID 10718480

Citations 7

Authors

R Turczyn

P Weiss

M Lapkowski

G Daculsi

Affiliations

Soon will be listed here.

Abstract

A new biomaterial is presented which consists of a cellulose derivative--silanised hydroxyethylcellulose (HEC-SIL) and biphasic calcium phosphate (BCP). Rheological properties of the polymer itself and its mixture with BCP are pH-dependent. At pH 10-12 HEC-SIL is liquid and undergoes quick gellation at pH < 9. Similarly, the paste of HEC-SIL and BCP is fluid and injectable at higher pH and solidifies in biological solutions. The rate of this solidification can be easily controlled by the degree of substitution of hydroxyethylcellulose with silicoalkoxy groups.

Citing Articles

Sudoku of porous, injectable calcium phosphate cements - Path to osteoinductivity.

Vezenkova A, Locs J Bioact Mater. 2022; 17:109-124.

PMID: 35386461 PMC: 8964990. DOI: 10.1016/j.bioactmat.2022.01.001.

A Cellulose/Laponite Interpenetrated Polymer Network (IPN) Hydrogel: Controllable Double-Network Structure with High Modulus.

Xie F, Boyer C, Gaborit V, Rouillon T, Guicheux J, Tassin J Polymers (Basel). 2019; 10(6).

PMID: 30966668 PMC: 6403786. DOI: 10.3390/polym10060634.

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications.

Dorozhkin S J Funct Biomater. 2015; 6(3):708-832.

PMID: 26262645 PMC: 4598679. DOI: 10.3390/jfb6030708.

Biocomposites and hybrid biomaterials based on calcium orthophosphates.

Dorozhkin S Biomatter. 2013; 1(1):3-56.

PMID: 23507726 PMC: 3548244. DOI: 10.4161/biom.1.1.16782.

Treatment of periodontal defects in dogs using an injectable composite hydrogel/biphasic calcium phosphate.

Struillou X, Boutigny H, Badran Z, Fellah B, Gauthier O, Sourice S J Mater Sci Mater Med. 2011; 22(7):1707-17.

PMID: 21611794 DOI: 10.1007/s10856-011-4344-1.

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