E-cadherin at the Cell Periphery is a Determinant of Keratinocyte Differentiation in Vitro

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 2000 Mar 10

PMID 10708559

Citations 8

Authors

D W Owens

V G Brunton

E K Parkinson

M C Frame

Affiliations

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Abstract

The origin of the signal for keratinocyte differentiation is still unknown. Here, we show that Ca(2+)- and density-induced translocation of E-cadherin, but not P-cadherin, is accompanied by induction of differentiation-specific proteins in cultured keratinocytes. Antibodies that artificially cluster cell-surface E-cadherin in low extracellular Ca(2+) also induce differentiation-specific proteins, implicating E-cadherin as a determinant of keratinocyte differentiation in vitro.

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