The Importance of Aquaporin Water Channel Protein Structures

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 2000 Mar 4

PMID 10698922

Citations 27

Authors

A Engel

Y Fujiyoshi

P Agre

Affiliations

Soon will be listed here.

Abstract

The history of the water channel and recent structural and functional analyses of aquaporins are reviewed. These ubiquitous channels are important for bacteria, plants and animals, exhibit a pronounced sequence homology and share functional as well as structural similarities. Aquaporins allow water or small specific solutes to pass unhindered, but block the passage of ions to prevent dissipation of the transmembrane potential. Besides advances in structure determination, recent experiments suggest that many of these channels are regulated by pH variations, phosphorylation and binding of auxiliary proteins.

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