Magnetoencephalography in Children with Landau-Kleffner Syndrome and Acquired Epileptic Aphasia

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 2000 Mar 1

PMID 10696012

Citations 3

Authors

D F Sobel

M Aung

H Otsubo

M C Smith

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Landau-Kleffner syndrome (LKS) is epileptiform aphasia acquired during childhood and occurring in children with previously normal language development. The epileptiform activity in these children is thought to result in a functional ablation of eloquent speech areas. The purpose of this study was to investigate the usefulness of magnetoencephalography (MEG) for localizing the source of epileptiform activity in these patients.

Methods: Nineteen patients with acquired aphasia and a suspected diagnosis of LKS were referred for MEG evaluation. Patients ranged in age from 4 to 14 years. Fourteen MEG studies were performed on a 74-channel system, four on a 148-channel whole-head system, and one on a 37-channel system.

Results: Thirteen of the 19 patients had perisylvian MEG spikes. In 10 of the patients, the spikes were bilateral, and in three they were unilateral. Four other patients had non-sylvian spikes, and two patients had no spikes recorded. The results of MR imaging were normal or noncontributory for all 19 patients.

Conclusions: MEG can play a useful role in evaluating children with LKS and acquired epileptiform aphasia, both in diagnosis and in aiding presurgical localization of epileptiform activity when surgery is being considered.

Citing Articles

Epileptic Encephalopathies with Status Epilepticus during Sleep: New Techniques for Understanding Pathophysiology and Therapeutic Options.

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Present status of surgical intervention for children with intractable seizures.

Depositario-Cabacar D, Riviello J, Takeoka M Curr Neurol Neurosci Rep. 2008; 8(2):123-9.

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Magnetoencephalography: clinical application in epilepsy.

Knowlton R Curr Neurol Neurosci Rep. 2003; 3(4):341-8.

PMID: 12930705 DOI: 10.1007/s11910-003-0012-2.

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