Distension-induced Myoelectrical Dysrhythmia and Effect of Intestinal Pacing in Dogs

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2000 Mar 1

PMID 10695625

Citations 10

Authors

M Abo

J Liang

L Qian

J D Chen

Affiliations

Soon will be listed here.

Abstract

The aims of this study were to investigate the effect of duodenal distension on intestinal myoelectrical activity and to investigate whether intestinal pacing was able to reverse the effects of distension. Six female hound dogs with four pairs of electrodes on the proximal jejunum were involved in this study. The protocol consisted of 30 min of recording of jejunal myoelectrical activity as baseline and 90 min of recording during distension. Intestinal pacing was performed during the second 30 min of distension. Duodenal distension severely impaired intestinal myoelectrical activity. The percentage of normal slow waves was reduced from 90.8+/-8.4% at baseline to 73.8+/-10.2%, 57.2+/-11.4%, and 53.7+/-16.0% during the first, second and third 30 min of distension (P<0.05, ANOVA). The dominant power was similarly decreased and the minute-by-minute variation of dominant frequency was significantly increased after distension. Intestinal pacing reversed distension-induced dysrhythmia. The percentage of normal slow waves during the 30 min of distension with pacing was significantly higher than the corresponding 30 min of distension without pacing (88.5+/-6.6% vs. 57.2+/-11.4%, P<0.03). It was concluded that intestinal pacing can normalize distension-induced dysrhythmia and has a potential as a future therapeutic modality for intestinal motor disorders.

Citing Articles

Optimization of pacing parameters to entrain slow wave activity in the pig jejunum.

Nagahawatte N, Avci R, Paskaranandavadivel N, Cheng L Sci Rep. 2024; 14(1):6038.

PMID: 38472365 PMC: 10933420. DOI: 10.1038/s41598-024-56256-2.

Systematic review of small intestine pacing parameters for modulation of gut function.

Nagahawatte N, Cheng L, Avci R, Angeli-Gordon T, Paskaranandavadivel N Neurogastroenterol Motil. 2022; 35(1):e14473.

PMID: 36194179 PMC: 10078404. DOI: 10.1111/nmo.14473.

Intestinal electric stimulation accelerates whole gut transit and promotes fat excrement in conscious rats.

Sun Y, Chen J Int J Obes (Lond). 2009; 33(8):817-23.

PMID: 19546870 PMC: 2725223. DOI: 10.1038/ijo.2009.123.

Effect of intestinal pacing on small bowel transit and nutrient absorption in healthy volunteers.

Liu J, Qiao X, Hou X, Chen J Obes Surg. 2008; 19(2):196-201.

PMID: 18704608 DOI: 10.1007/s11695-008-9533-8.

Inhibitory effects of sildenafil on small intestinal motility and myoelectrical activity in dogs.

Xu X, Chen J Dig Dis Sci. 2006; 51(4):671-6.

PMID: 16614987 DOI: 10.1007/s10620-006-3190-3.

References

Rutgers L, Kuiper R, van der Velden M . Effects of experimental duodenal occlusion on electrical activity of the proximal duodenum in cattle. Res Vet Sci. 1988; 45(2):186-93. View

Morrison P, Kelly K . Increasing antidumping effect of intestinal pacing with motor-active agents. Dig Dis Sci. 1986; 31(4):422-7. DOI: 10.1007/BF01311680. View

Chen J, Stewart Jr W, McCallum R . Spectral analysis of episodic rhythmic variations in the cutaneous electrogastrogram. IEEE Trans Biomed Eng. 1993; 40(2):128-35. DOI: 10.1109/10.212066. View

Schuffler M . Chronic intestinal pseudo-obstruction syndromes. Med Clin North Am. 1981; 65(6):1331-58. DOI: 10.1016/s0025-7125(16)31475-4. View

Akwari O, Kelley K, Steinbach J, Code C . Electric pacing of intact and transected canine small intestine and its computer model. Am J Physiol. 1975; 229(5):1188-97. DOI: 10.1152/ajplegacy.1975.229.5.1188. View

Collin J, Kelly K, Phillips S . Absorption from the jejunum is increased by forward and backward pacing. Br J Surg. 1979; 66(7):489-92. DOI: 10.1002/bjs.1800660712. View

Summers R, Yanda R, Prihoda M, Flatt A . Acute intestinal obstruction: an electromyographic study in dogs. Gastroenterology. 1983; 85(6):1301-6. View

Hermon-Taylor J, Code C . Localization of the duodenal pacemaker and its role in the organization of duodenal myoelectric activity. Gut. 1971; 12(1):40-7. PMC: 1411469. DOI: 10.1136/gut.12.1.40. View

Prihoda M, Flatt A, Summers R . Mechanisms of motility changes during acute intestinal obstruction in the dog. Am J Physiol. 1984; 247(1 Pt 1):G37-42. DOI: 10.1152/ajpgi.1984.247.1.G37. View

10.

OConnell P, Kelly K . Enteric transit and absorption after canine ileostomy. Effect of pacing. Arch Surg. 1987; 122(9):1011-7. DOI: 10.1001/archsurg.1987.01400210049007. View

11.

Gladen H, Kelly K . Electrical pacing for short bowel syndrome. Surg Gynecol Obstet. 1981; 153(5):697-700. View

12.

Karlstrom L, Kelly K . Ectopic jejunal pacemakers and gastric emptying after Roux gastrectomy: effect of intestinal pacing. Surgery. 1989; 106(5):867-71. View

13.

Abell T, Kim C, Malagelada J . Idiopathic cyclic nausea and vomiting--a disorder of gastrointestinal motility?. Mayo Clin Proc. 1988; 63(12):1169-75. DOI: 10.1016/s0025-6196(12)65401-9. View

14.

You C, Chey W, Lee K, MENGUY R, BORTOFF A . Gastric and small intestinal myoelectric dysrhythmia associated with chronic intractable nausea and vomiting. Ann Intern Med. 1981; 95(4):449-51. DOI: 10.7326/0003-4819-95-4-449. View

15.

Sullivan M, Snape Jr W, Matarazzo S, Petrokubi R, Jeffries G, Cohen S . Gastrointestinal myoelectrical activity in idiopathic intestinal pseudo-obstruction. N Engl J Med. 1977; 297(5):233-8. DOI: 10.1056/NEJM197708042970501. View

16.

Antoncic R, Lawson H . THE MUSCULAR ACTIVITY OF THE SMALL INTESTINE, IN THE DOG, DURING ACUTE OBSTRUCTION. Ann Surg. 1941; 114(3):415-23. PMC: 1385772. DOI: 10.1097/00000658-194109000-00008. View

17.

Sawchuk A, Canal D, Grosfeld J, Slaughter M, Gardner G, OConnor T . Electrical pacing of the Roux limb resolves delayed gastric emptying. J Surg Res. 1987; 42(6):635-41. DOI: 10.1016/0022-4804(87)90007-2. View

18.

Reiser S, Weiser H, Schusdziarra V, Siewert J . Effect of pacing on small intestinal motor activity and hormonal response in dogs. Dig Dis Sci. 1989; 34(4):579-84. DOI: 10.1007/BF01536336. View

19.

Lin X, Peters L, Hayes J, Chen J . Entrainment of segmental small intestinal slow waves with electrical stimulation in dogs. Dig Dis Sci. 2000; 45(4):652-6. DOI: 10.1023/a:1005466904380. View

20.

Layzell T, Collin J . Retrograde electrical pacing of the small intestine--a new treatment for the short bowel syndrome?. Br J Surg. 1981; 68(10):711-3. DOI: 10.1002/bjs.1800681012. View