SAP Family Proteins

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 2000 Mar 1

PMID 10694467

Citations 29

Authors

A Fujita

Y Kurachi

Affiliations

Soon will be listed here.

Abstract

Thus far, five members including Dlg, SAP97/hDlg, SAP90/PSD-95, SAP102, and PSD-93/chapsyn110 which belong to SAP family have been identified. Recent studies have revealed that these proteins play important roles in the localization and function of glutamate receptors and K(+) channels. Although most of them have been reported to be localized to the synapse, only one member, SAP97, is expressed also in the epithelial cells. In this review, we have summarized structural characters of SAP family proteins and discuss their functions in neurons and epithelial cells.

Citing Articles

Effects of citicoline administration on synaptic proteins in rapid eye movement sleep-deprived rats.

Cakir A, Ocalan B, Cansu C, Gulec Suyen G, Cansev M, Kahveci N Iran J Basic Med Sci. 2022; 25(5):562-568.

PMID: 35911643 PMC: 9282749. DOI: 10.22038/IJBMS.2022.60756.

Molecular determinants of beta-adrenergic signaling to voltage-gated K channels in the cerebral circulation.

Rhee S, Rusch N Microcirculation. 2017; 25(1).

PMID: 29072364 PMC: 6407422. DOI: 10.1111/micc.12425.

WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene .

Hennig K, Fass D, Zhao W, Sheridan S, Fu T, Erdin S Mol Neuropsychiatry. 2017; 3(1):53-71.

PMID: 28879201 PMC: 5582445. DOI: 10.1159/000475666.

Barcoding of GPCR trafficking and signaling through the various trafficking roadmaps by compartmentalized signaling networks.

Bahouth S, Nooh M Cell Signal. 2017; 36:42-55.

PMID: 28449947 PMC: 5512170. DOI: 10.1016/j.cellsig.2017.04.015.

ErbB2 and p38γ MAPK mediate alcohol-induced increase in breast cancer stem cells and metastasis.

Xu M, Ren Z, Wang X, Comer A, Frank J, Ke Z Mol Cancer. 2016; 15(1):52.

PMID: 27416801 PMC: 4944437. DOI: 10.1186/s12943-016-0532-4.