The Structure of a Stable Intermediate in the A <--> B DNA Helix Transition

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2000 Feb 26

PMID 10688897

Citations 38

Authors

H L Ng

M L Kopka

R E DICKERSON

Affiliations

Soon will be listed here.

Abstract

The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.

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