Molecular Determinants of Drug Resistance in Tuberculosis

Overview

Journal Int J Tuberc Lung Dis

Specialty Pulmonary Medicine

Date 2000 Feb 25

PMID 10688142

Citations 39

Authors

P F Riska

W R Jacobs Jr

D Alland

Affiliations

Soon will be listed here.

Abstract

Rapid detection of drug-resistant tuberculosis (TB) has become increasingly important in the era of pandemic human immunodeficiency virus infection and antibiotic resistance. The identification of the molecular correlates of antibiotic resistance in Mycobacterium tuberculosis have engendered the development of DNA-based assays for the identification of drug-resistant TB. This review summarizes the recent discoveries concerning resistance to isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin, amikacin, kanamycin and the quinolones.

Citing Articles

Scalable de novo classification of antibiotic resistance of Mycobacterium tuberculosis.

Serajian M, Marini S, Alanko J, Noyes N, Prosperi M, Boucher C Bioinformatics. 2024; 40(Suppl 1):i39-i47.

PMID: 38940175 PMC: 11211809. DOI: 10.1093/bioinformatics/btae243.

Accurate and affordable detection of rifampicin and isoniazid resistance in Tuberculosis sputum specimens by multiplex PCR-multiple probes melting analysis.

Xie L, Zhu X, Xu L, Xu X, Ruan Z, Huang M Infection. 2024; 52(6):2371-2398.

PMID: 38884858 PMC: 11621165. DOI: 10.1007/s15010-024-02295-w.

Tuberculosis Severity Predictive Model Using Mtb Variants and Serum Biomarkers in a Colombian Cohort of APTB Patients.

Ocampo J, Alzate J, Barrera L, Baena A Biomedicines. 2023; 11(12).

PMID: 38137331 PMC: 10740695. DOI: 10.3390/biomedicines11123110.

Detection of Isoniazid and Rifampin Resistance in Mycobacterium tuberculosis Clinical Isolates from Sputum Samples by High-Resolution Melting Analysis.

Parsa S, Yaghoubi A, Izadi N, Sabet F, Nik L, Derakhshan M Curr Microbiol. 2022; 79(9):257.

PMID: 35852629 DOI: 10.1007/s00284-022-02960-z.

Inactivation of a New Potassium Channel Increases Rifampicin Resistance and Induces Collateral Sensitivity to Hydrophilic Antibiotics in .

Do T, Rodriguez-Beltran J, Cebrian-Sastre E, Rodriguez-Rojas A, Castaneda-Garcia A, Blazquez J Antibiotics (Basel). 2022; 11(4).

PMID: 35453260 PMC: 9025972. DOI: 10.3390/antibiotics11040509.