Gene Structure of Human Cholecystokinin (CCK) Type-A Receptor: Body Fat Content is Related to CCK Type-A Receptor Gene Promoter Polymorphism

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2000 Feb 22

PMID 10682840

Citations 14

Authors

A Funakoshi

K Miyasaka

H Matsumoto

S Yamamori

S Takiguchi

K Kataoka

Y Takata

K Matsusue

A Kono

H Shimokata

Affiliations

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Abstract

The transcriptional start site of the human cholecystokinin (CCK)-A receptor gene was determined by the Capsite Hunting method. Two sequence changes were detected, a G to T change in nucleotide -128, and an A to G change in nucleotide -81. The homozygote (T/T, G/G) was detected in 25 of 1296 individuals (1.9%) in the cohort study. This polymorphism showed a significantly higher percent body fat and higher levels of serum insulin and leptin, compared with wild type and heterozygotes. Our study provided the possibility that polymorphism in the promoter region of the CCK-A receptor gene may be one of genetic factors affecting fat deposition.

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