Lipopolysaccharides of Brucella Abortus and Brucella Melitensis Induce Nitric Oxide Synthesis in Rat Peritoneal Macrophages

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2000 Feb 26

PMID 10679001

Citations 6

Authors

L Lopez-Urrutia

A Alonso

M L Nieto

Y Bayon

A Orduna

M Sanchez Crespo

Affiliations

Soon will be listed here.

Abstract

Smooth lipopolysaccharide (S-LPS) and lipid A of Brucella abortus and Brucella melitensis induced the production of nitric oxide (NO) by rat adherent peritoneal cells, but they induced lower levels of production of NO than Escherichia coli LPS. The participation of the inducible isoform of NO synthase (iNOS) was confirmed by the finding of an increased expression of both iNOS mRNA and iNOS protein. These observations might help to explain (i) the acute outcome of Brucella infection in rodents, (ii) the low frequency of septic shock in human brucellosis, and (iii) the prolonged intracellular survival of Brucella in humans.

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