Chemical Hepatocarcinogenesis in Transgenic Mice Overexpressing Mature TGF Beta-1 in Liver

Overview

Journal Eur J Cancer

Specialty Oncology

Date 2000 Feb 16

PMID 10674001

Citations 6

Authors

J SCHNUR

P Nagy

A Sebestyen

Z Schaff

S S Thorgeirsson

Affiliations

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Abstract

The role of transforming growth factor beta 1 (TGF-beta 1) in carcinogenesis is a controversial issue. Certain results suggest a promoter role of this growth factor whilst in other experimental models TGF-beta 1 seems to inhibit the process of tumorigenesis. In an attempt to resolve this problem, we have performed chemical hepatocarcinogenesis experiments on transgenic mice expressing a high level of active TGF-beta 1 in their liver. Transgenic production of TGF-beta 1 did not result in spontaneous tumour formation during our observation period. However, two carcinogens, thioacetamide and N-OH acetylaminofluorene, were more potent in transgenic than in wild-type mice, whereas aflatoxin B1 was equally effective in both groups. Our observations suggest that an increased level of TGF-beta 1 in the liver does not provide protection against the effect of chemical carcinogens.

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