Effect of Hochu-ekki-to (TJ-41), a Japanese Herbal Medicine, on the Survival of Mice Infected with Influenza Virus

Overview

Journal Antiviral Res

Publisher Elsevier

Date 2000 Feb 11

PMID 10669260

Citations 22

Authors

K Mori

T Kido

H Daikuhara

I Sakakibara

T Sakata

K Shimizu

S Amagaya

H Sasaki

Y Komatsu

Affiliations

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Abstract

The antiviral effect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, was investigated using mice infected with influenza virus. TJ-41 was found to increase the survival rate, prolong the mean survival days, suppress viral growth in bronchoalveolar labage fluid (BALF) and inhibit the lung index (lung consolidation) on day 4 after infection in mice infected with influenza, after the agent had been administered orally once daily from day 7 to 2 before infection and from day 0 to 4 after infection. Administration of TJ-41 decreased the BALF concentrations of IL-1alpha, IL-6 and GM-CSF, but not TNF-alpha or interferon-gamma (IFN-gamma), on day 4 after infection. In addition, TJ-41 elevated the level of IFN-alpha in BALF on day 2 after infection. Yet, TJ-41 did not show any inhibitory effect on the growth of influenza virus in vitro. These results suggest that TJ-41 exerts its inhibitory effect on influenza virus infection via enhancement of the host immune responses in this experimental murine system.

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