Persistent Hantavirus Infections: Characteristics and Mechanisms

Overview

Journal Trends Microbiol

Date 2000 Feb 9

PMID 10664598

Citations 81

Authors

B J Meyer

C S Schmaljohn

Affiliations

Soon will be listed here.

Abstract

Hantaviruses include serious human pathogens that are maintained in nature in persistently infected rodents and that can also persistently infect cultured mammalian cells, causing little or no cytopathology. The mechanisms of hantavirus persistence are only beginning to be explored. Recent data point to subtle changes in the viral genome that might result in the differential regulation of replication and lead to persistence.

Citing Articles

Comparative genetic analysis of pathogenic and attenuated strains of Junín virus.

Thomas P, Ferrer M, Lozano M, Gomez R Genetica. 2025; 153(1):12.

PMID: 39921799 DOI: 10.1007/s10709-025-00228-5.

A study on the codon usage bias of arenavirus common genes.

Thomas P, Ferrer M, Lozano M, Gomez R Front Microbiol. 2025; 15:1490076.

PMID: 39917269 PMC: 11799557. DOI: 10.3389/fmicb.2024.1490076.

A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs.

Goodfellow S, Nofchissey R, Ye C, Banther-McConnell J, Suriyamongkol T, Cook J PLoS Pathog. 2025; 21(1):e1012849.

PMID: 39836687 PMC: 11785344. DOI: 10.1371/journal.ppat.1012849.

In silico design of multi-epitope vaccines against the hantaviruses by integrated structural vaccinology and molecular modeling approaches.

Ali L, Rauf S, Khan A, Rasool S, Raza R, Alshabrmi F PLoS One. 2024; 19(7):e0305417.

PMID: 39042625 PMC: 11265663. DOI: 10.1371/journal.pone.0305417.

Infection with mpox virus via the genital mucosae increases shedding and transmission in the multimammate rat (Mastomys natalensis).

Port J, Riopelle J, Smith S, Myers L, Kaiser F, Lewis M Nat Microbiol. 2024; 9(5):1231-1243.

PMID: 38649413 DOI: 10.1038/s41564-024-01666-1.