The Role of Epidemiology in the Detection of Harmful Effects of Radiation

Overview

Journal Environ Health Perspect

Date 2000 Feb 5

PMID 10656847

Citations 7

Authors

A Stewart

Affiliations

Soon will be listed here.

Abstract

Data relating to acute injuries of atomic bomb survivors show that the life span study cohort is biased in favor of exceptionally low levels of radiosensitivity. These data also show that factors influencing the death rates of this cohort include irreversible damage to the immune system. These impressions are still awaiting confirmation. Meanwhile, the Oxford Survey of Childhood Cancers and surveys of nuclear workers show that at low dose levels the cancer risk is much greater than estimates based on atomic bomb survivors; the special association between leukemia and radiation is an exclusively high dose effect, and levels of radiosensitivity are much lower in the middle of the life span than at either extreme.

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References

Yoshimoto Y, Kato H, Schull W . Risk of cancer among children exposed in utero to A-bomb radiations, 1950-84. Lancet. 1988; 2(8612):665-9. DOI: 10.1016/s0140-6736(88)90477-1. View

Stewart A . Delayed effects of A-bomb radiation: a review of recent mortality rates and risk estimates for five-year survivors. J Epidemiol Community Health. 1982; 36(2):80-6. PMC: 1052900. DOI: 10.1136/jech.36.2.80. View

Cardis E, Gilbert E, Carpenter L, Howe G, Kato I, Armstrong B . Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries. Radiat Res. 1995; 142(2):117-32. View

Stewart A, Kneale G . The immune system and cancers of foetal origin. Cancer Immunol Immunother. 1982; 14(2):110-6. PMC: 11039191. DOI: 10.1007/BF00200178. View

Neriishi K, Stram D, Vaeth M, Mizuno S, Akiba S . The observed relationship between the occurrence of acute radiation effects and leukemia mortality among A-bomb survivors. Radiat Res. 1991; 125(2):206-13. View

Shimizu Y, Kato H, Schull W, Hoel D . Studies of the mortality of A-bomb survivors. 9. Mortality, 1950-1985: Part 3. Noncancer mortality based on the revised doses (DS86). Radiat Res. 1992; 130(2):249-66. View

Gilbert E, Marks S . An analysis of the mortality of workers in a nuclear facility. Radiat Res. 1979; 79(1):122-48. View

MANCUSO T, Stewart A, Kneale G . Radiation exposures of Hanford workers dying from cancer and other causes. Health Phys. 1977; 33:369-85. DOI: 10.1097/00004032-197711000-00002. View

Stewart A, Kneale G . A-bomb survivors: further evidence of late effects of early deaths. Health Phys. 1993; 64(5):467-72. DOI: 10.1097/00004032-199305000-00002. View

10.

Stewart A, Kneale G . A-bomb radiation and evidence of late effects other than cancer. Health Phys. 1990; 58(6):729-35. DOI: 10.1097/00004032-199006000-00004. View

11.

Ritz B, Morgenstern H, Froines J, Young B . Effects of exposure to external ionizing radiation on cancer mortality in nuclear workers monitored for radiation at Rocketdyne/Atomics International. Am J Ind Med. 1999; 35(1):21-31. DOI: 10.1002/(sici)1097-0274(199901)35:1<21::aid-ajim4>3.0.co;2-x. View

12.

Jablon S, Ishida M, Yamasaki M . STUDIES OF THE MORTALITY OF A-BOMB SURVIVORS. 3. DESCRIPTION OF THE SAMPLE AND MORTALITY, 1950--1960. Radiat Res. 1965; 25:25-52. View

13.

Kneale G . Excess sensitivity of pre-leukaemics to pneumonia. A model situation for studying the interaction of infectious disease with cancer. Br J Prev Soc Med. 1971; 25(3):152-9. PMC: 478646. DOI: 10.1136/jech.25.3.152. View

14.

Hewitt D . Some features of leukaemia mortality. Br J Prev Soc Med. 1955; 9(2):81-8. PMC: 1058581. DOI: 10.1136/jech.9.2.81. View

15.

Stewart A . Detecting the health risks of radiation. Med Confl Surviv. 1999; 15(2):138-48. DOI: 10.1080/13623699908409448. View

16.

Stewart A, Webb J, Hewitt D . A survey of childhood malignancies. Br Med J. 1958; 1(5086):1495-508. PMC: 2029590. DOI: 10.1136/bmj.1.5086.1495. View

17.

DOLL R, Wakeford R . Risk of childhood cancer from fetal irradiation. Br J Radiol. 1997; 70:130-9. DOI: 10.1259/bjr.70.830.9135438. View

18.

Kneale G, Stewart A . Age variation in the cancer risks from foetal irradiation. Br J Cancer. 1977; 36(4):501-10. PMC: 2025372. DOI: 10.1038/bjc.1977.220. View

19.

Kneale G, MANCUSO T, Stewart A . Hanford radiation study III: a cohort study of the cancer risks from radiation to workers at Hanford (1944-77 deaths) by the method of regression models in life-tables. Br J Ind Med. 1981; 38(2):156-66. PMC: 1008839. DOI: 10.1136/oem.38.2.156. View

20.

Stewart A . Childhood cancers and competing causes of death. Leuk Res. 1995; 19(2):103-11. DOI: 10.1016/0145-2126(94)00122-q. View