Vaccines and the Induction of Functional Antibodies: Time to Look Beyond the Molecules of Natural Infection?

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2000 Feb 2

PMID 10655088

Citations 22

Authors

D R Burton

P W Parren

Affiliations

Soon will be listed here.

Abstract

Infection with some pathogens induces weak functional antibody responses that are non-protective, and there has been some skepticism about a role for antibodies in vaccine design. However, newer data show that antibodies can protect against infection with these pathogens, and new methods to elicit production of functional antibodies should be sought.

Citing Articles

Subdominance in Antibody Responses: Implications for Vaccine Development.

Lindahl G Microbiol Mol Biol Rev. 2020; 85(1).

PMID: 33239435 PMC: 7709521. DOI: 10.1128/MMBR.00078-20.

The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization.

Lei L, Yang Y, Tran K, Wang Y, Chiang C, Ozorowski G Cell Rep. 2019; 27(2):586-598.e6.

PMID: 30970260 PMC: 6458978. DOI: 10.1016/j.celrep.2019.03.039.

Anti-HIV-1 response elicited in rabbits by anti-idiotype monoclonal antibodies mimicking the CD4-binding site.

Burioni R, Mancini N, De Marco D, Clementi N, Perotti M, Nitti G PLoS One. 2008; 3(10):e3423.

PMID: 18923648 PMC: 2565497. DOI: 10.1371/journal.pone.0003423.

A simple one-step method for the preparation of HIV-1 envelope glycoprotein immunogens based on a CD4 mimic peptide.

Martin G, Sun Y, Heyd B, Combes O, Ulmer J, Descours A Virology. 2008; 381(2):241-50.

PMID: 18835005 PMC: 2645002. DOI: 10.1016/j.virol.2008.08.039.

Immune modulating effect by a phosphoprotein-deleted rabies virus vaccine vector expressing two copies of the rabies virus glycoprotein gene.

Cenna J, Tan G, Papaneri A, Dietzschold B, Schnell M, McGettigan J Vaccine. 2008; 26(50):6405-14.

PMID: 18804506 PMC: 2629409. DOI: 10.1016/j.vaccine.2008.08.069.