Six Years' Experience of Prophylactic Oral Vitamin K

Overview

Journal Arch Dis Child Fetal Neonatal Ed

Specialties Gynecology & Obstetrics
Pediatrics

Date 2000 Jan 15

PMID 10634845

Citations 13

Authors

U Wariyar

S Hilton

J Pagan

W Tin

E Hey

Affiliations

Soon will be listed here.

Abstract

Aims: The ability of oral vitamin K to eliminate all risk of vitamin K deficiency bleeding during the first three months of life was studied.

Methods: Babies (n=182,000) in the north of England judged well enough to be offered milk within 12 hours of birth were given 1 mg of phytomenadione (vitamin K(1)) suspended in a medium chain triglyceride oil by mouth at delivery between 1993 and 1998. The parents of those who were breastfed were given a further three doses to give to the baby once every two weeks after discharge.

Results: Four breastfed babies developed late vitamin K deficiency bleeding. In two, staff failed to follow policy guidelines, and in two there was undiagnosed alpha(1) antitrypsin deficiency. Audit suggested that 93% of breastfed babies had all four doses, as advised.

Conclusions: An oral product that parents can administer themselves would be popular if licensed, but the total dose offered may need to be more than in this study if babies with undiagnosed liver disease are to be protected.

Citing Articles

Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant.

Fiesack S, Smits A, Rayyan M, Allegaert K, Alliet P, Arts W Nutrients. 2021; 13(11).

PMID: 34836364 PMC: 8621883. DOI: 10.3390/nu13114109.

Refusal of Intramuscular Vitamin K by Parents of Newborns: A Review.

Loyal J, Shapiro E Hosp Pediatr. 2020; 10(3):286-294.

PMID: 32019806 PMC: 7041551. DOI: 10.1542/hpeds.2019-0228.

Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk.

Lowensteyn Y, Jansen N, VAN Heerde M, Klein R, Kneyber M, Kuiper J Eur J Pediatr. 2019; 178(7):1033-1042.

PMID: 31062090 PMC: 6565637. DOI: 10.1007/s00431-019-03391-y.

Incidence of late vitamin K deficiency bleeding in newborns in the Netherlands in 2005: evaluation of the current guideline.

IJland M, Pereira R, Cornelissen E Eur J Pediatr. 2007; 167(2):165-9.

PMID: 17333271 PMC: 2151775. DOI: 10.1007/s00431-007-0443-x.

Hemothorax as presentation of late vitamin-K-deficient bleeding in a 1-month-old infant with homozygous alpha-1-antitrypsin deficiency.

Huybrechts S, Wojciechowski M, Poot S, Van Reempts P, Ramet J Eur J Pediatr. 2006; 166(10):1081-2.

PMID: 17124588 DOI: 10.1007/s00431-006-0351-5.

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