Reference Ranges for Plasma Cystatin C and Creatinine Measurements in Premature Infants, Neonates, and Older Children

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 2000 Jan 12

PMID 10630919

Citations 102

Authors

H Finney

D J Newman

H Thakkar

J M Fell

C P Price

Affiliations

Soon will be listed here.

Abstract

Aim: To establish a reference range in the paediatric population for the new glomerular filtration rate (GFR) marker, cystatin C, and to compare it with that of creatinine.

Methods: Cystatin C and creatinine were measured by particle enhanced nephelometric immunoassay (PENIA) and fixed interval Jaff¿e methods, respectively, in 291 children aged 1 day to 17 years, including 30 premature infants with gestational ages ranging from 24 to 36 weeks.

Results: In the premature infants, concentrations of both cystatin C and creatinine were significantly raised compared with term infants, with cystatin C concentrations being between 1.10 and 2.06 mg/litre and creatinine between 32 and 135 micromol/litre. In premature infants, there was no significant relation between gestational age and cystatin C or creatinine concentration. Creatinine concentrations fell to a nadir at 4 months of age, rising gradually to adult values by about 15-17 years of age, in contrast to cystatin C, which fell to a mean concentration of 0.80 mg/litre by the 1st year of life, and remained constant throughout adulthood up to the age of 50 years. Neither analyte showed any influence of sex.

Conclusion: The measurement of cystatin C, rather than creatinine, is more practical for monitoring GFR changes in the paediatric population.

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