Inhibition by 16,16-dimethyl Prostaglandin E2 of Tumor Necrosis Factor-alpha and Interleukin-1beta Production and Messenger RNA Expression in Human Monocytes Stimulated by Helicobacter Pylori

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2000 Jan 12

PMID 10630489

Citations 4

Authors

O Takaishi

T Arakawa

Y Fujiwara

T Fukuda

K Otani

K Yamasaki

K Higuchi

T Kuroki

Affiliations

Soon will be listed here.

Abstract

We investigated the effects of 16,16-dimethyl prostaglandin E2 on the production of tumor necrosis factor-alpha and interleukin-1beta in human monocytes stimulated with Helicobacter pylori. Monocytes isolated from human peripheral blood were incubated for 24 hr with the extract of H. pylori diluted 1:100 to 1:100,000 by volume, a combination of the extract and 16,16-dimethyl prostaglandin E2, or a vehicle alone. The extract stimulated the production of tumor necrosis factor-alpha and interleukin-1beta and the expression of their messenger RNA in a dose-dependent manner. 16,16-Dimethyl prostaglandin E2 inhibited the production of these cytokines and their messenger RNA in the presence of H. pylori at doses higher than 10(-6) M, predominantly with tumor necrosis factor-alpha. These data suggest that antiinflammatory effects of prostaglandins on gastric mucosa are in part related to their effects on inhibition of production of proinflammatory cytokines by monocytes.

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References

Kassai K, Yoshikawa T, Yoshida N, Hashiramoto A, Kondo M, Murase H . Helicobacter pylori water extract induces interleukin-8 production by gastric epithelial cells. Dig Dis Sci. 1999; 44(2):237-42. DOI: 10.1023/a:1026629812245. View

Amano S, Naganuma K, Kawata Y, Kawakami K, Kitano S, Hanazawa S . Prostaglandin E2 stimulates osteoclast formation via endogenous IL-1 beta expressed through protein kinase A. J Immunol. 1996; 156(5):1931-6. View

Yoshida N, Granger D, Evans Jr D, Evans D, Graham D, Anderson D . Mechanisms involved in Helicobacter pylori-induced inflammation. Gastroenterology. 1993; 105(5):1431-40. DOI: 10.1016/0016-5085(93)90148-6. View

Harris P, Mobley H, Perez-Perez G, Blaser M, Smith P . Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production. Gastroenterology. 1996; 111(2):419-25. DOI: 10.1053/gast.1996.v111.pm8690207. View

Blaser M . Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation. Gastroenterology. 1992; 102(2):720-7. DOI: 10.1016/0016-5085(92)90126-j. View

Mai U, Perez-Perez G, Wahl L, Wahl S, Blaser M, Smith P . Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism. J Clin Invest. 1991; 87(3):894-900. PMC: 329879. DOI: 10.1172/JCI115095. View

Wallace J . Prostaglandins, NSAIDs, and cytoprotection. Gastroenterol Clin North Am. 1992; 21(3):631-41. View

Kunkel S, Wiggins R, Chensue S, Larrick J . Regulation of macrophage tumor necrosis factor production by prostaglandin E2. Biochem Biophys Res Commun. 1986; 137(1):404-10. DOI: 10.1016/0006-291x(86)91224-6. View

Baggiolini M, Walz A, Kunkel S . Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest. 1989; 84(4):1045-9. PMC: 329758. DOI: 10.1172/JCI114265. View

10.

Yamaoka Y, Kita M, Kodama T, Sawai N, Imanishi J . Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa. Gastroenterology. 1996; 110(6):1744-52. DOI: 10.1053/gast.1996.v110.pm8964399. View

11.

Goodwin C, Armstrong J, Marshall B . Campylobacter pyloridis, gastritis, and peptic ulceration. J Clin Pathol. 1986; 39(4):353-65. PMC: 499829. DOI: 10.1136/jcp.39.4.353. View

12.

Kunkel S, Spengler M, May M, Spengler R, Larrick J, Remick D . Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression. J Biol Chem. 1988; 263(11):5380-4. View

13.

Obayashi T, Tamura H, Tanaka S, Ohki M, Takahashi S, Arai M . A new chromogenic endotoxin-specific assay using recombined limulus coagulation enzymes and its clinical applications. Clin Chim Acta. 1985; 149(1):55-65. DOI: 10.1016/0009-8981(85)90273-6. View

14.

Graham D . Campylobacter pylori and peptic ulcer disease. Gastroenterology. 1989; 96(2 Pt 2 Suppl):615-25. DOI: 10.1016/s0016-5085(89)80057-5. View

15.

Santucci L, Fiorucci S, Di Matteo F, Morelli A . Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats. Gastroenterology. 1995; 108(2):393-401. DOI: 10.1016/0016-5085(95)90065-9. View

16.

Crabtree J, Shallcross T, Heatley R, Wyatt J . Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut. 1991; 32(12):1473-7. PMC: 1379245. DOI: 10.1136/gut.32.12.1473. View

17.

Spengler R, Spengler M, Lincoln P, Remick D, Strieter R, Kunkel S . Dynamics of dibutyryl cyclic AMP- and prostaglandin E2-mediated suppression of lipopolysaccharide-induced tumor necrosis factor alpha gene expression. Infect Immun. 1989; 57(9):2837-41. PMC: 313535. DOI: 10.1128/iai.57.9.2837-2841.1989. View

18.

Appleyard C, McCafferty D, Tigley A, Swain M, Wallace J . Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence. Am J Physiol. 1996; 270(1 Pt 1):G42-8. DOI: 10.1152/ajpgi.1996.270.1.G42. View

19.

Wallace J . Possible mechanisms and mediators of gastritis associated with Helicobacter pylori infection. Scand J Gastroenterol Suppl. 1991; 187:65-70. View

20.

Peek Jr R, Miller G, Tham K, Perez-Perez G, Zhao X, Atherton J . Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains. Lab Invest. 1995; 73(6):760-70. View