The Prognostic Role of Vessel Productive Changes and Vessel Density in Oligodendroglioma

Overview

Journal J Neurooncol

Publisher Springer

Date 2000 Jan 5

PMID 10619493

Citations 12

Authors

D Schiffer

I Bosone

A Dutto

N Di Vito

A Chio

Affiliations

Soon will be listed here.

Abstract

The recognition of the anaplastic variant of oligodendroglioma is difficult, since it is not easy to identify histological prognostic factors. Among the latter, vascular productive changes have been inconsistently put in relation with survival. In 95 cases of operated oligodendrogliomas, endothelial cell hyperplasia, microvascular proliferations and capillary density were studied by histological and immunohistochemical methods. Capillary density was evaluated on CD31-stained sections by a grid of 100 squares placed in the ocular of the microscope. Statistical analysis was performed in order to compare these parameters with survival. A nodular growth pattern was observed more frequently among tumor grades 3-4 than among tumor grades 1-2. Endothelial cell hyperplasia was more frequent in nodular growth pattern, but it did not correlate with survival. The highest capillary density was found in nodular growth pattern, but it did not correlate with survival as well. Microvascular proliferations correlated with survival only in univariate, but not in multivariate analysis. Age, extent of surgical removal, year of surgery, post-operative Karnofsky score and MIB-1 LI remained associated with survival, as observed in a previous study.

Citing Articles

Probing the glioma microvasculature: a case series of the comparison between perfusion MRI and intraoperative high-frame-rate ultrafast Doppler ultrasound.

Alafandi A, Tbalvandany S, Arzanforoosh F, Van der Voort S, Incekara F, Verhoef L Eur Radiol Exp. 2024; 8(1):13.

PMID: 38273190 PMC: 10810769. DOI: 10.1186/s41747-023-00406-0.

Differential diagnosis of oligodendroglial and astrocytic tumors using imaging results: the added value of perfusion MR imaging.

Yoon H, Ahn K, Lee S, Jang J, Choi H, Jung S Neuroradiology. 2017; 59(7):665-675.

PMID: 28550465 DOI: 10.1007/s00234-017-1851-x.

Perfusion and diffusion MRI signatures in histologic and genetic subtypes of WHO grade II-III diffuse gliomas.

Leu K, Ott G, Lai A, Nghiemphu P, Pope W, Yong W J Neurooncol. 2017; 134(1):177-188.

PMID: 28547590 PMC: 7927357. DOI: 10.1007/s11060-017-2506-9.

Glomeruloid microvascular proliferation is associated with lack of response to chemotherapy in breast cancer.

Akslen L, Straume O, Geisler S, Sorlie T, Chi J, Aas T Br J Cancer. 2011; 105(1):9-12.

PMID: 21673677 PMC: 3137417. DOI: 10.1038/bjc.2011.203.

Multiparametric characterization of grade 2 glioma subtypes using magnetic resonance spectroscopic, perfusion, and diffusion imaging.

Bian W, Khayal I, Lupo J, McGue C, Vandenberg S, Lamborn K Transl Oncol. 2009; 2(4):271-80.

PMID: 19956389 PMC: 2781083. DOI: 10.1593/tlo.09178.

References

Daumas-Duport C, Scheithauer B, OFallon J, Kelly P . Grading of astrocytomas. A simple and reproducible method. Cancer. 1988; 62(10):2152-65. DOI: 10.1002/1097-0142(19881115)62:10<2152::aid-cncr2820621015>3.0.co;2-t. View

Heegaard S, Sommer H, Broholm H, Broendstrup O . Proliferating cell nuclear antigen and Ki-67 immunohistochemistry of oligodendrogliomas with special reference to prognosis. Cancer. 1995; 76(10):1809-13. DOI: 10.1002/1097-0142(19951115)76:10<1809::aid-cncr2820761020>3.0.co;2-i. View

Schiffer D, Chio A, Giordana M, Mauro A, Migheli A, Vigliani M . The vascular response to tumor infiltration in malignant gliomas. Morphometric and reconstruction study. Acta Neuropathol. 1989; 77(4):369-78. DOI: 10.1007/BF00687371. View

Wesseling P, Schlingemann R, Rietveld F, Link M, Burger P, Ruiter D . Early and extensive contribution of pericytes/vascular smooth muscle cells to microvascular proliferation in glioblastoma multiforme: an immuno-light and immuno-electron microscopic study. J Neuropathol Exp Neurol. 1995; 54(3):304-10. DOI: 10.1097/00005072-199505000-00003. View

Shaw E, Scheithauer B, OFallon J, Tazelaar H, Davis D . Oligodendrogliomas: the Mayo Clinic experience. J Neurosurg. 1992; 76(3):428-34. DOI: 10.3171/jns.1992.76.3.0428. View

Daumas-Duport C, Tucker M, Kolles H, Cervera P, Beuvon F, Varlet P . Oligodendrogliomas. Part II: A new grading system based on morphological and imaging criteria. J Neurooncol. 1997; 34(1):61-78. DOI: 10.1023/a:1005759220434. View

Mork S, Halvorsen T, Lindegaard K, Eide G . Oligodendroglioma. Histologic evaluation and prognosis. J Neuropathol Exp Neurol. 1986; 45(1):65-78. DOI: 10.1097/00005072-198601000-00006. View

Daumas-Duport C, Varlet P, Tucker M, Beuvon F, Cervera P, Chodkiewicz J . Oligodendrogliomas. Part I: Patterns of growth, histological diagnosis, clinical and imaging correlations: a study of 153 cases. J Neurooncol. 1997; 34(1):37-59. DOI: 10.1023/a:1005707203596. View

Kros J, Pieterman H, Van Eden C, Avezaat C . Oligodendroglioma: the Rotterdam-Dijkzigt experience. Neurosurgery. 1994; 34(6):959-66; discussion 966. DOI: 10.1227/00006123-199406000-00002. View

10.

Kyritsis A, Yung W, BRUNER J, Gleason M, Levin V . The treatment of anaplastic oligodendrogliomas and mixed gliomas. Neurosurgery. 1993; 32(3):365-70; discussion 371. DOI: 10.1227/00006123-199303000-00005. View

11.

Celli P, Nofrone I, Palma L, CANTORE G, Fortuna A . Cerebral oligodendroglioma: prognostic factors and life history. Neurosurgery. 1994; 35(6):1018-34; discussion 1034-5. DOI: 10.1227/00006123-199412000-00003. View

12.

Bosari S, Lee A, DeLellis R, Wiley B, Heatley G, Silverman M . Microvessel quantitation and prognosis in invasive breast carcinoma. Hum Pathol. 1992; 23(7):755-61. DOI: 10.1016/0046-8177(92)90344-3. View

13.

Haddad S, Moore S, Schelper R, Goeken J . Vascular smooth muscle hyperplasia underlies the formation of glomeruloid vascular structures of glioblastoma multiforme. J Neuropathol Exp Neurol. 1992; 51(5):488-92. DOI: 10.1097/00005072-199209000-00002. View

14.

Peto R, Pike M, Armitage P, Breslow N, Cox D, Howard S . Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977; 35(1):1-39. PMC: 2025310. DOI: 10.1038/bjc.1977.1. View

15.

FISCHER V, Siddiqi A, Yusufaly Y . Altered angioarchitecture in selected areas of brains with Alzheimer's disease. Acta Neuropathol. 1990; 79(6):672-9. DOI: 10.1007/BF00294246. View

16.

Peterson K, Cairncross J . Oligodendrogliomas. Neurol Clin. 1995; 13(4):861-73. View

17.

Christov C, Adle-Biassette H, Le Guerinel C, Natchev S, Gherardi R . Immunohistochemical detection of vascular endothelial growth factor (VEGF) in the vasculature of oligodendrogliomas. Neuropathol Appl Neurobiol. 1998; 24(1):29-35. DOI: 10.1046/j.1365-2990.1998.00091.x. View

18.

Schiffer D, Dutto A, Cavalla P, Bosone I, Chio A, Villani R . Prognostic factors in oligodendroglioma. Can J Neurol Sci. 1997; 24(4):313-9. DOI: 10.1017/s0317167100032984. View

19.

Cairncross J, Macdonald D . Successful chemotherapy for recurrent malignant oligodendroglioma. Ann Neurol. 1988; 23(4):360-4. DOI: 10.1002/ana.410230408. View

20.

Leighton C, Fisher B, Bauman G, Depiero S, Stitt L, MacDonald D . Supratentorial low-grade glioma in adults: an analysis of prognostic factors and timing of radiation. J Clin Oncol. 1997; 15(4):1294-301. DOI: 10.1200/JCO.1997.15.4.1294. View