» Articles » PMID: 10599847

5-HT1A Autoreceptor Desensitization by Chronic Ultramild Stress in Mice

Overview
Journal Neuroreport
Specialty Neurology
Date 1999 Dec 22
PMID 10599847
Citations 29
Authors
Affiliations
Soon will be listed here.
Abstract

Electrophysiological and biochemical approaches were used to assess possible changes in central 5-HT neurotransmission in mice that had been subjected to chronic ultramild stress for 8 weeks. This treatment produced a significant decrease in the potency of the 5-HT1A agonist ipsapirone to inhibit the electrical activity of serotoninergic neurons in the dorsal raphe nucleus, without modifying 5-HT1A receptor binding in various brain areas. These data demonstrate that chronic ultramild stress triggers a long term and durable functional desensitization of somatodendritic 5-HT1A autoreceptors in mice.

Citing Articles

Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway.

Sakai Y, Li H, Inaba H, Funayama Y, Ishimori E, Kawatake-Kuno A iScience. 2021; 24(5):102504.

PMID: 34113835 PMC: 8170005. DOI: 10.1016/j.isci.2021.102504.


Delayed Antidepressant Efficacy and the Desensitization Hypothesis.

Commons K, Linnros S ACS Chem Neurosci. 2019; 10(7):3048-3052.

PMID: 30807103 PMC: 7340170. DOI: 10.1021/acschemneuro.8b00698.


Evidence for intact 5-HT receptor-mediated feedback inhibition following sustained antidepressant treatment in a rat model of depression.

Babb J, Linnros S, Commons K Neuropharmacology. 2018; 141:139-147.

PMID: 30170082 PMC: 6170686. DOI: 10.1016/j.neuropharm.2018.08.032.


Response of Htr3a knockout mice to antidepressant treatment and chronic stress.

Martin V, Riffaud A, Marday T, Brouillard C, Franc B, Tassin J Br J Pharmacol. 2017; 174(15):2471-2483.

PMID: 28493335 PMC: 5513867. DOI: 10.1111/bph.13857.


Input-specific contributions to valence processing in the amygdala.

Correia S, Goosens K Learn Mem. 2016; 23(10):534-43.

PMID: 27634144 PMC: 5026206. DOI: 10.1101/lm.037887.114.