Alpha 2.0
Login Register
» Articles » PMID: 10596256

A Meta-analysis of Clonidine for Symptoms of Attention-deficit Hyperactivity Disorder

Overview
Journal J Am Acad Child Adolesc Psychiatry
Publisher Elsevier
Specialties Pediatrics
Psychiatry
Date 1999 Dec 22
PMID 10596256
Citations 63
Authors
D F Connor
K E Fletcher
J M Swanson
Affiliations
Soon will be listed here.
Abstract

Objective: Meta-analysis was used to review the literature on the clinical use of clonidine to treat symptoms of attention-deficit hyperactivity disorder (ADHD).

Method: A review of the literature from 1980 to 1999 revealed 39 studies that reported clonidine's efficacy and side effects for symptoms of ADHD and comorbid conditions. Of these, 11 reports provided sufficient information to be included in a meta-analysis.

Results: Meta-analysis using weighted variables revealed clonidine demonstrates a moderate effect size of 0.58 +/- 0.16 (95% confidence interval = 0.27-0.89) on symptoms of ADHD in children and adolescents with ADHD and ADHD comorbid with conduct disorder, developmental delay, and tic disorders.

Conclusions: Clonidine may be an effective second-tier treatment for symptoms of ADHD, but it has an effect size less than that of stimulants. Clinical use of clonidine is associated with many side effects.

Citing Articles

Incremental Validity of ADHD Dimensions in the Predictions of Emotional Symptoms, Conduct Problems, and Peer Problems in Adolescents Based on Parent, Teacher, and Self-Ratings.

Gomez R, Brown T Pediatr Rep. 2024; 16(4):1115-1133.

PMID: 39728736 PMC: 11677613. DOI: 10.3390/pediatric16040095.

Optimal Dosing Recommendations of Clonidine in Pediatrics Using Physiologically Based Pharmacokinetic Modeling.

Yellepeddi V, Bayless S, Parrot M, Sherwin C J Pediatr Pharmacol Ther. 2024; 29(6):636-644.

PMID: 39659862 PMC: 11627573. DOI: 10.5863/1551-6776-29.6.636.

A 6-year-old with childhood absence epilepsy and motor hyperactivity.

Auvin S Epilepsy Behav Rep. 2024; 26:100660.

PMID: 38532901 PMC: 10963181. DOI: 10.1016/j.ebr.2024.100660.

A systematic meta-review of systematic reviews on attention deficit hyperactivity disorder.

Chaulagain A, Lyhmann I, Halmoy A, Widding-Havneraas T, Nyttingnes O, Bjelland I Eur Psychiatry. 2023; 66(1):e90.

PMID: 37974470 PMC: 10755583. DOI: 10.1192/j.eurpsy.2023.2451.

Epilepsy and Attention Deficit Hyperactivity Disorder: Connection, Chance, and Challenges.

Fan H, Chiang K, Chang K, Chen C, Tsai J Int J Mol Sci. 2023; 24(6).

PMID: 36982345 PMC: 10049646. DOI: 10.3390/ijms24065270.