Insulin-like Growth Factor I: an Attractive Option for Chronic Heart Failure?

Overview

Journal Drugs Aging

Specialties Geriatrics
Pharmacology

Date 1999 Dec 3

PMID 10582772

Citations 2

Authors

M Y Donath

J Zapf

Affiliations

Soon will be listed here.

Abstract

Chronic congestive heart failure is a syndrome with a poor prognosis. Currently, the only therapy providing the possibility of long term survival is heart transplantation. Therefore, new therapeutic strategies continue to be investigated. One such new approach may be the application of recombinant human insulin-like growth factor (IGF)-1. IGF-1 has both acute and long term cardiovascular effects. Acute administration of IGF-1 resulted in a reduction in afterload and positive inotropic effects in patients with heart failure. In vitro and animal studies have demonstrated that IGF-1 can stimulate myofibril formation. In addition, IGF-1 administration has beneficial metabolic effects. The benefits of prolonged IGF-1 therapy have yet to be investigated.

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References

Gluckman P, Guan J, Beilharz E, Klempt N, Klempt M, Miller O . The role of the insulin-like growth factor system in neuronal rescue. Ann N Y Acad Sci. 1993; 692:138-48. DOI: 10.1111/j.1749-6632.1993.tb26212.x. View

Flyvbjerg A, JORGENSEN K, Marshall S, Orskov H . Inhibitory effect of octreotide on growth hormone-induced IGF-I generation and organ growth in hypophysectomized rats. Am J Physiol. 1991; 260(4 Pt 1):E568-74. DOI: 10.1152/ajpendo.1991.260.4.E568. View

Winterhalter K, Schmid C, FROESCH E, Zapf J . Expression and regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone. Endocrinology. 1994; 135(6):2558-67. DOI: 10.1210/endo.135.6.7527334. View

Donath M, Zapf J, Eppenberger-Eberhardt M, FROESCH E, Eppenberger H . Insulin-like growth factor I stimulates myofibril development and decreases smooth muscle alpha-actin of adult cardiomyocytes. Proc Natl Acad Sci U S A. 1994; 91(5):1686-90. PMC: 43228. DOI: 10.1073/pnas.91.5.1686. View

NIKKILA E, PELKONEN R . Serum lipids in acromegaly. Metabolism. 1975; 24(7):829-38. DOI: 10.1016/0026-0495(75)90129-8. View

Muta K, Krantz S, Bondurant M, Wickrema A . Distinct roles of erythropoietin, insulin-like growth factor I, and stem cell factor in the development of erythroid progenitor cells. J Clin Invest. 1994; 94(1):34-43. PMC: 296279. DOI: 10.1172/JCI117327. View

Buerke M, Murohara T, Skurk C, Nuss C, Tomaselli K, Lefer A . Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Proc Natl Acad Sci U S A. 1995; 92(17):8031-5. PMC: 41280. DOI: 10.1073/pnas.92.17.8031. View

Bennett M, Evan G, Schwartz S . Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest. 1995; 95(5):2266-74. PMC: 295839. DOI: 10.1172/JCI117917. View

Cuneo R, Salomon F, Wilmshurst P, Byrne C, Wiles C, Hesp R . Cardiovascular effects of growth hormone treatment in growth-hormone-deficient adults: stimulation of the renin-aldosterone system. Clin Sci (Lond). 1991; 81(5):587-92. DOI: 10.1042/cs0810587. View

10.

Donath M, Sutsch G, Yan X, Piva B, Brunner H, Glatz Y . Acute cardiovascular effects of insulin-like growth factor I in patients with chronic heart failure. J Clin Endocrinol Metab. 1998; 83(9):3177-83. DOI: 10.1210/jcem.83.9.5122. View

11.

Martins J, Kerber R, Sherman B, Marcus M, Ehrhardt J . Cardiac size and function in acromegaly. Circulation. 1977; 56(5):863-9. DOI: 10.1161/01.cir.56.5.863. View

12.

Fazio S, Sabatini D, Capaldo B, Vigorito C, Giordano A, Guida R . A preliminary study of growth hormone in the treatment of dilated cardiomyopathy. N Engl J Med. 1996; 334(13):809-14. DOI: 10.1056/NEJM199603283341301. View

13.

Genth-Zotz S, Zotz R, Geil S, Voigtlander T, Meyer J, Darius H . Recombinant growth hormone therapy in patients with ischemic cardiomyopathy : effects on hemodynamics, left ventricular function, and cardiopulmonary exercise capacity. Circulation. 1999; 99(1):18-21. DOI: 10.1161/01.cir.99.1.18. View

14.

Copeland K, Nair K . Recombinant human insulin-like growth factor-I increases forearm blood flow. J Clin Endocrinol Metab. 1994; 79(1):230-2. DOI: 10.1210/jcem.79.1.8027233. View

15.

Rodriguez-Tarduchy G, Collins M, Garcia I, Lopez-Rivas A . Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells. J Immunol. 1992; 149(2):535-40. View

16.

Christofori G, Naik P, Hanahan D . A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature. 1994; 369(6479):414-8. DOI: 10.1038/369414a0. View

17.

Guler H, Schmid C, Zapf J, FROESCH E . Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects. Proc Natl Acad Sci U S A. 1989; 86(8):2868-72. PMC: 287020. DOI: 10.1073/pnas.86.8.2868. View

18.

FROESCH E, Hussain M . Recombinant human insulin-like growth factor-I: a therapeutic challenge for diabetes mellitus. Diabetologia. 1994; 37 Suppl 2:S179-85. DOI: 10.1007/BF00400842. View

19.

Guler H, Zapf J, Scheiwiller E, FROESCH E . Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats. Proc Natl Acad Sci U S A. 1988; 85(13):4889-93. PMC: 280542. DOI: 10.1073/pnas.85.13.4889. View

20.

Daughaday W, Hall K, RABEN M, SALMON Jr W, VAN DEN BRANDE J, Van Wyk J . Somatomedin: proposed designation for sulphation factor. Nature. 1972; 235(5333):107. DOI: 10.1038/235107a0. View