TIN2, a New Regulator of Telomere Length in Human Cells

Overview

Journal Nat Genet

Specialty Genetics

Date 1999 Dec 2

PMID 10581025

Citations 206

Authors

S H Kim

P Kaminker

J Campisi

Affiliations

Soon will be listed here.

Abstract

Telomeres are DNA-protein structures that cap linear chromosomes and are essential for maintaining genomic stability and cell phenotype. We identified a novel human telomere-associated protein, TIN2, by interaction cloning using the telomeric DNA-binding-protein TRF1 as a bait. TIN2 interacted with TRF1 in vitro and in cells, and co-localized with TRF1 in nuclei and metaphase chromosomes. A mutant TIN2 that lacks amino-terminal sequences effects elongated human telomeres in a telomerase-dependent manner. Our findings suggest that TRF1 is insufficient for control of telomere length in human cells, and that TIN2 is an essential mediator of TRF1 function.

Citing Articles

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