Synchronous Ileal Autotransplantation Impairs Adaptation of Remaining Gut in Pigs with Proximal Small Bowel Resection

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1999 Nov 26

PMID 10573361

Citations 4

Authors

J Lauronen

M P Pakarinen

P Kuusanmaki

E Savilahti

P Vento

T Paavonen

J Halttunen

Affiliations

Soon will be listed here.

Abstract

This study investigates the effects of ileal autotransplantation on morphology, crypt cell proliferation, and brush border disaccharidases of the remaining jejunoileum and colon in growing pigs with 75% proximal small bowel resection. Resection was performed on 30 pigs, of which 15 underwent an autotransplantation of the remaining ileum. The autotransplanted pigs showed reduced weight gain and remnant ileal length when compared to the resected controls. In the autotransplanted pigs, small bowel diameter and weight, mucosal weight and protein content, villus height and surface area, crypt depth, and the number of proliferating crypt cells were reduced similarly both in the intact jejunum and in the autotransplanted ileal remnant. Autotransplantation also decreased the number of proliferative crypt cells of the colon. Specific activities of maltase and sucrase tended to increase in the autotransplanted ileal remnant, whereas the total enzyme activities decreased. These results suggest that ileal autotransplantation disturbs postresectional adaptation of the remaining gut.

Citing Articles

Small bowel review: Diseases of the small intestine.

Thomson A, Drozdowski L, Iordache C, Thomson B, Vermeire S, Clandinin M Dig Dis Sci. 2003; 48(8):1582-99.

PMID: 12924653 DOI: 10.1023/a:1024776125966.

Role of extrinsic innervation in jejunal absorptive adaptation to subtotal small bowel resection: a model of segmental small bowel transplantation.

Libsch K, Zyromski N, Tanaka T, Kendrick M, Haidenberg J, Peia D J Gastrointest Surg. 2002; 6(2):240-7.

PMID: 11992810 DOI: 10.1016/s1091-255x(01)00074-9.

Ileal absorptive adaptation to jejunal resection and extrinsic denervation: implications for living-related small bowel transplantation.

Tsiotos G, Kendrick M, Libsch K, Bierens K, Lankisch P, Duenes J J Gastrointest Surg. 2002; 5(5):517-24.

PMID: 11986003 DOI: 10.1016/s1091-255x(01)80090-1.

Effects of extrinsic denervation with or without ischemia-reperfusion injury on constitutional mucosal characteristics in porcine jejunoileum.

Lauronen J, Pakarinen M, Pirinen P, Kuusanmaki P, Raivio P, Savilahti E Dig Dis Sci. 2001; 46(3):476-85.

PMID: 11318518 DOI: 10.1023/a:1005674426690.

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