Blastic Transformation of Mantle Cell Lymphoma: Genetic Evidence for a Clonal Link Between the Two Stages of the Tumour

Overview

Journal Histopathology

Specialties Anatomy & Histology
Pathology

Date 1999 Nov 17

PMID 10564390

Citations 3

Authors

T Laszlo

A Matolcsy

Affiliations

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Abstract

Aims: The blastic variant of mantle cell lymphoma (MCL-BV) may develop through histological transformation of mantle cell lymphoma (MCL). However, the clonal link between the tumour cells of MCL and transformed MCL-BV has not been established at the genetic level. To investigate this link longitudinal molecular genetic studies have been performed in two cases of MCL that showed morphological transformation to MCL-BV.

Methods And Results: Polymerase chain reaction (PCR) and nucleotide sequence analyses of the complementary determining region 3 (CDR) of the immunoglobulin (Ig) heavy chain (H) gene were performed to identify clone-specific rearrangements. In both cases, nucleotide sequence analysis revealed common clone-specific IgH gene rearrangements in MCL and subsequent MCL-BV.

Conclusions: These results provide genetic evidence for the common clonal origin of MCL and subsequently developed MCL-BV.

Citing Articles

Blastic Transformation of a Mantle Cell Lymphoma Presenting as an Enlarging Unilateral Orbital Mass.

De Niear M, Greer J, Seegmiller A, Mawn L Ocul Oncol Pathol. 2019; 5(4):245-251.

PMID: 31367585 PMC: 6615325. DOI: 10.1159/000492832.

Mantle cell lymphoma shows three morphological evolutions of classical, intermediate, and aggressive forms, which occur in parallel with increased labeling index of cyclin D1 and Ki-67.

Kimura Y, Sato K, Arakawa F, Karube K, Nomura Y, Shimizu K Cancer Sci. 2009; 101(3):806-14.

PMID: 20002441 PMC: 11158152. DOI: 10.1111/j.1349-7006.2009.01433.x.

Growth pattern and distribution of follicular dendritic cells in mantle cell lymphoma: a clinicopathological study of 96 patients.

Schrader C, Meusers P, Brittinger G, Janssen D, Teymoortash A, Siebmann J Virchows Arch. 2005; 448(2):151-9.

PMID: 16133361 DOI: 10.1007/s00428-005-0049-5.